Abstract
To study the functional recovery of a patient with cerebrovascular injury using combined functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI). A 24-year-old woman with left hemianopsia underwent fMRI and DTI in a 1.5-tesla machine both in the acute phase and 1 month after an ischaemic stroke involving the right calcarine cortex. Acute-phase fMRI demonstrated that peripheral left visual field stimulation did not activate the right primary visual cortex, whereas stimulation 1 month later activated the visual cortex bilaterally. Analysis of acute-phase DTI data disclosed that a reduction of fractional anisotropy in the right optic radiation had almost resolved after 1 month. Fibre direction was normal at either time point. fMRI and DTI can demonstrate functional damage and recovery in patients with neuro-ophthalmological lesions.
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References
Jenkins WM, Merzenich MM (1987) Reorganization of neocortical representations after brain injury: a neurophysiological model of the bases of recovery from stroke. Prog Brain Res 71:249–266
Seitz RJ, Butefisch CM, Kleiser R, Homberg V (2004) Reorganisation of cerebral circuits in human ischemic brain disease. Restor Neurol Neurosci 22:207–229
Gerloff C, Bushara K, Sailer A, Wassermann EM, Chen R, Matsuoka T, Waldvogel D, Wittenberg GF, Ishii K, Cohen LG, Hallett M (2006) Multimodal imaging of brain reorganization in motor areas of the contralesional hemisphere of well recovered patients after capsular stroke. Brain 129:791–808
Weiller C, Ramsay SC, Wise RJ, Friston KJ, Frackowiak RS (1993) Individual patterns of functional reorganization in the human cerebral cortex after capsular infarction. Ann Neurol 33:181–189
Rossini PM, Altamura C, Ferretti A et al (2004) Does cerebrovascular disease affect the coupling between neuronal activity and local haemodynamics? Brain 127:99–110
Pineiro R, Pendlebury S, Johansen-Berg H, Matthews PM (2002) Altered hemodynamic responses in patients after subcortical stroke measured by functional MRI. Stroke 33:103–109
Murata Y, Sakatani K, Hoshino T, Fujiwara N, Kano T et al (2006) Effects of cerebral ischemia on evoked cerebral blood oxygenation responses and BOLD contrast functional MRI in stroke patients. Stroke 37:2514
Bonaiuti D, Grimaldi M (2007) Neuroimaging: a new challenge in neurorehabilitation of stroke patients. Eura Medicophys 43:215–219
Wieshmann UC, Krakow K, Symms MR, Parker GJM, Clark CA, Barker GJ, Shorvon SD (2001) Combined functional magnetic resonance imaging and diffusion tensor imaging demonstrate widespread modified organisation in malformation of cortical development. J Neurol Neurosurg Psychiatry 70:521–523
Ward NS (2007) Future perspectives in functional neuroimaging in stroke recovery. Eura Medicophys 43:285–294
Cramer SC, Nelles G, Benson RR, Kaplan JD et al (1997) A functional MRI study of subjects recovered from hemiparetic stroke. Stroke 28:2518–2527
Cramer SC, Nelles G, Judith D, Schaechter JD et al (2001) A functional MRI study of three motor tasks in the evaluation of stroke recovery. Neurorehabil Neural Repair 15:1–8
Bütefisch CM, Kleiser R, Seitz RJ (2006) Post-lesional cerebral reorganisation: evidence from functional neuroimaging and transcranial magnetic stimulation. J Physiol Paris 99:437–454
Carusone LM, Srinivasan J, Gitelman DR, Mesulam MM, Parrish TB (2002) Hemodynamic response changes in cerebrovascular disease: implications for functional MR imaging. Am J Neuroradiol 23:1222–1228
Cao Y, D’Olhaberriague L, Vikingstad EM, Levine SR, Welch KM (1998) Pilot study of functional MRI to assess cerebral activation of motor function after poststroke hemiparesis. Stroke 29:112–122
Binkofski F, Seitz RJ (2004) Modulation of the BOLD-response in early recovery from sensorimotor stroke. Neurology 63:1223–1229
Krainik A, Hund-Georgiadis M, Zysset S, von Cramon Y (2005) Regional impairment of cerebrovascular reactivity and BOLD signal in adults after stroke. Stroke 36:1146
Schmid LM, Rosa MG, Calford MB, Ambler JS (1996) Visuotopic reorganization in the primary visual cortex of adult cats following monocular and binocular retinal lesions. Cereb Cortex 6:388–405
Catani M, Jones DK, Donato R, Ffytche DH (2003) Occipito-temporal connections in the human brain. Brain 126:2093–2107
Dougherty RF, Ben-Shachar M, Bammer R, Brewer AA, Wandell BA (2005) Functional organization of human occipital–callosal fiber tracts. Proc Natl Acad Sci USA 102:7350–7355
Yamada K, Mori S, Nakamura H et al (2003) Fiber-tracking method reveals sensorimotor pathway involvement in stroke patients. Stroke 34:159–162
Bridge H, Thomas O, Jbabdi S, Cowey A (2008) Changes in connectivity after visual cortical brain damage underlie altered visual function. Brain 131:1433–1444
Oldfield RC (1971) The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia 9:97–113
Talairach J, Tournoux P (1988) Co-planar stereotaxic atlas of the human brain. Thieme, Stuttgart
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Polonara, G., Salvolini, S., Fabri, M. et al. Unilateral visual loss due to ischaemic injury in the right calcarine region: a functional magnetic resonance imaging and diffusion tension imaging follow-up study. Int Ophthalmol 31, 129–134 (2011). https://doi.org/10.1007/s10792-011-9420-5
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DOI: https://doi.org/10.1007/s10792-011-9420-5