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Morphological changes in the retinal pigment epithelium on spectral-domain OCT in the unaffected eyes with idiopathic central serous chorioretinopathy

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Abstract

Purpose To report the changes seen in the retinal pigment epithelium (RPE) morphology in the asymptomatic eyes of patients with idiopathic central serous chorioretinopathy (ICSC) using spectral-domain Cirrus TM high-definition optical coherence tomography (HD-OCT). Methods In a prospective case series, 17 consecutive patients with unilateral ICSC underwent spectral-domain Cirrus TM HD-OCT scans for both affected and opposite asymptomatic eye. Three-dimensional single-layer RPE map was studied in both eyes for morphological alterations, and findings were correlated with clinical presentation, fluorescein angiogram, and 5 Line raster scan. Additionally, three-dimensional (3D) single-layer RPE maps done in 111 healthy volunteers served as control. Results In patients with ICSC, 3D single-layer RPE analysis of asymptomatic eyes showed presence of RPE bumps in 16 (94%) eyes and pigment epithelium detachment (PED) in 2 (11.8%) eyes. The 5 Line raster scan was normal in all eyes. Of 222 normal (control) scans, 18 showed RPE bumps and none showed PED. Conclusions 3D single-layer RPE map showed abnormal pattern in the asymptomatic eyes of patients with unilateral ICSC. Summary Spectral-domain optical coherence tomography showed morphologic alterations in retinal pigment epithelium in both eyes of patients with idiopathic central serous chorioretinopathy.

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Authors and Affiliations

  1. Department of Ophthalmology, Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India

    Pawan Gupta, Vishali Gupta, M. R. Dogra, Ramandeep Singh & Amod Gupta

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  1. Pawan Gupta
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  2. Vishali Gupta
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  3. M. R. Dogra
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  4. Ramandeep Singh
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  5. Amod Gupta
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Correspondence to Amod Gupta.

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Gupta, P., Gupta, V., Dogra, M.R. et al. Morphological changes in the retinal pigment epithelium on spectral-domain OCT in the unaffected eyes with idiopathic central serous chorioretinopathy. Int Ophthalmol 30, 175–181 (2010). https://doi.org/10.1007/s10792-009-9302-2

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  • DOI: https://doi.org/10.1007/s10792-009-9302-2

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