International Ophthalmology

, Volume 30, Issue 2, pp 149–173 | Cite as

A clinical approach to the diagnosis of retinal vasculitis

  • Ahmed M. Abu El-AsrarEmail author
  • Carl P. Herbort
  • Khalid F. Tabbara


Retinal vasculitis is a sight-threatening inflammatory eye condition that involves the retinal vessels. Detection of retinal vasculitis is made clinically, and is confirmed with the help of fundus fluorescein angiography. Active vascular disease is characterized by exudates around retinal vessels resulting in white sheathing or cuffing of the affected vessels. In this review, a practical approach to the diagnosis of retinal vasculitis is discussed based on ophthalmoscopic and fundus fluorescein angiographic findings.


Retina Vasculitis Fluorescein angiography 



The authors thank Ms. Connie B. Unisa-Marfil for secretarial work. This work was supported by Medical Research Chair in Ophthalmology funded by Dr. Naser Al-Rasheed.


  1. 1.
    Abu El-Asrar AM, Herbort CP, Tabbara KF (2005) Retinal vasculitis. Ocul Immunol Inflamm 13:415–433. doi: 10.1080/09273940591003828 PubMedGoogle Scholar
  2. 2.
    Arnold AC, Usaf M, Pepose JS, Hepler RS, Foos RY (1984) Retinal periphlebitis and retinitis in multiple sclerosis. I. Pathologic characteristics. Ophthalmology 91:255–262PubMedGoogle Scholar
  3. 3.
    Gass JD, Olson CL (1976) Sarcoidosis with optic nerve and retinal involvement. Arch Ophthalmol 94:945–950PubMedGoogle Scholar
  4. 4.
    Charteris DG, Champ C, Rosenthal AR, Lightman SL (1992) Behçet’s disease: activated T lymphocytes in retinal perivasculitis. Br J Ophthalmol 76:499–501. doi: 10.1136/bjo.76.8.499 PubMedGoogle Scholar
  5. 5.
    Pederson JE, Kenyon KR, Green WR, Maumenee AE (1978) Pathology of pars planitis. Am J Ophthalmol 86:762–774PubMedGoogle Scholar
  6. 6.
    Gaudio PA, Kaye DB, Crawford JB (2002) Histopathology of birdshot retinochoroidopathy. Br J Ophthalmol 86:1439–1441. doi: 10.1136/bjo.86.12.1439 PubMedGoogle Scholar
  7. 7.
    Perez VL, Chavala SH, Ahmed M, Chu D, Zafirakis P, Baltatzis S, Ocampo V, Foster CS (2004) Ocular manifestations and concepts of systemic vasculitides. Surv Ophthalmol 49:399–418. doi: 10.1016/j.survophthal.2004.04.008 PubMedGoogle Scholar
  8. 8.
    Graham EM, Spalton DJ, Barnard RO, Garner A, Russell RW (1985) Cerebral and retinal vascular changes in systemic lupus erythematosus. Ophthalmology 92:444–448PubMedGoogle Scholar
  9. 9.
    Au A, O’Day J (2004) Review of severe vaso-occlusive retinopathy in systemic lupus erythematosus and the antiphosopholipid syndrome: associations, visual outcomes, complications and treatment. Clin Exp Ophthalmol 32:87–100. doi: 10.1046/j.1442-9071.2004.00766.x Google Scholar
  10. 10.
    Palmer HE, Stanford MR, Sanders MD, Graham EM (1996) Visual outcome of patients with idiopathic ischaemic and non-ischaemic retinal vasculitis. Eye 10:343–348PubMedGoogle Scholar
  11. 11.
    Saatci OA, Koçak N, Durak I, Ergin MH (2001) Unilateral retinal vasculitis, branch retinal artery occlusion and subsequent retinal neovascularization in Crohn’s disease. Int Ophthalmol 24:89–92. doi: 10.1023/A:1016351800466 PubMedGoogle Scholar
  12. 12.
    Abu El-Asrar AM, Naddaf HO, Al-Momen A, Al-Balla SR (1995) Systemic lupus erythematosus flare-up manifesting as a cilioretinal artery occlusion. Lupus 4:158–160. doi: 10.1177/096120339500400216 Google Scholar
  13. 13.
    Iida T, Spaide RF, Kantor J (2002) Retinal and choroidal arterial occlusion in Wegener’s granulomatosis. Am J Ophthalmol 133:151–152. doi: 10.1016/S0002-9394(01)01251-X PubMedGoogle Scholar
  14. 14.
    Hsu CT, Kerrison JB, Miller NR, Goldberg MF (2001) Choroidal infarction, ischemic optic neuropathy, and central retinal artery occlusion from polyarteritis nodosa. Retina 21:348–351. doi: 10.1097/00006982-200108000-00009 PubMedGoogle Scholar
  15. 15.
    Skrapari I, Kagkelari E, Charitatos E, Pantelidaki C, Gounaris T, Sioula E (2008) Acute painless monocular visual loss due to central retinal artery occlusion in a patient with Churg–Strauss vasculitis. Clin Rheumatol 27:125–127. doi: 10.1007/s10067-007-0695-x PubMedGoogle Scholar
  16. 16.
    Johnson MW, Thomley ML, Huang SS, Gass JDM (1994) Idiopathic recurrent branch retinal arterial occlusion. Natural history and laboratory evaluation. Ophthalmology 101:480–489PubMedGoogle Scholar
  17. 17.
    Emad Y, Basaffar S, Ragab Y, Zeinhom F, Gheita T (2007) A case of polyarteritis nodosa complicated by left central retinal artery occlusion, ischemic optic neuropathy, and retinal vasculitis. Clin Rheumatol 26:814–816. doi: 10.1007/s10067-006-0270-x PubMedGoogle Scholar
  18. 18.
    Bentley CR, Stanford MR, Shilling JS, Sanders MD, Graham EM (1993) Macular ischaemia in posterior uveitis. Eye 7:411–414PubMedGoogle Scholar
  19. 19.
    Abu El-Asrar AM, AL-Kharashi SA (2002) Full panretinal photocoagulation and early vitrectomy improve prognosis of retinal vasculitis associated with tuberculoprotein hypersensitivity. Br J Ophthalmol 86:1248–1251. doi: 10.1136/bjo.86.11.1248 Google Scholar
  20. 20.
    Vine AK (1992) Severe periphlebitis, peripheral retinal ischemia, and preretinal neovascularization in patients with multiple sclerosis. Am J Ophthalmol 113:28–32PubMedGoogle Scholar
  21. 21.
    Morse PH (1975) Retinal venous sheathing and neovascularization in disseminated sclerosis. Ann Ophthalmol 7:949–952PubMedGoogle Scholar
  22. 22.
    Valentincic NV, Kraut A, Rothova A (2007) Vitreous hemorrhage in multiple sclerosis-associated uveitis. Ocul Immunol Inflamm 15:19–25. doi: 10.1080/09273940601147737 PubMedGoogle Scholar
  23. 23.
    Jabs DA, Fine SL, Hochberg MC, Newman SA, Heiner GG, Stevens MB (1986) Severe retinal vaso-occlusive disease in systemic lupus erythematosus. Arch Ophthalmol 104:558–563PubMedGoogle Scholar
  24. 24.
    Salmon JF, Ursell PG, Frith P (2000) Neovascular glaucoma as a complication of retinal vasculitis in Crohn’s disease. Am J Ophthalmol 130:528–530. doi: 10.1016/S0002-9394(00)00609-7 PubMedGoogle Scholar
  25. 25.
    Abu El-Asrar AM, Al-Obeidan SA, Abdel Gader AGM (2003) Retinal periphlebitis resembling frosted branch angiitis with nonperfused central retinal vein occlusion. Eur J Ophthalmol 13:807–812PubMedGoogle Scholar
  26. 26.
    Sakane T, Takeno M (2000) Novel approaches to Behçet’s disease. Expert Opin Investig Drugs 9:1993–2005. doi: 10.1517/13543784.9.9.1993 PubMedGoogle Scholar
  27. 27.
    Okada AA (2000) Drug therapy in Behçet’s disease. Ocul Immunol Inflamm 8:85–91. doi: 10.1076/0927-3948(200006)8:2;1-0;FT085 PubMedGoogle Scholar
  28. 28.
    Graham EM, Stanford MR, Sander MD, Kasp E, Dumonde DC (1989) A point prevalence study of 150 patients with idiopathic retinal vasculitis: I. Diagnostic value of ophthalmological features. Br J Ophthalmol 73:714–721. doi: 10.1136/bjo.73.9.714 PubMedGoogle Scholar
  29. 29.
    Gold DH, Morris DA, Hertrind P (1972) Ocular findings in systemic lupus erythematosus. Br J Ophthalmol 56:800–804. doi: 10.1136/bjo.56.11.800 PubMedGoogle Scholar
  30. 30.
    Lanham JG, Barrie T, Kohner EM, Hughes GRVO (1982) SLE retinopathy: evaluation by fluorescein angiography. Ann Rheum Dis 41:473–478. doi: 10.1136/ard.41.5.473 PubMedGoogle Scholar
  31. 31.
    Asherson RA, Merry P, Acheson JF, Harris EN, Hughes GRV (1989) Antiphospholipid antibodies: a risk factor for occlusive ocular vascular disease in systemic lupus erythematosus and the primary antiphospholipid syndrome. Ann Rheum Dis 48:358–361. doi: 10.1136/ard.48.5.358 PubMedGoogle Scholar
  32. 32.
    Quillen DA, Stathopoulos NA, Blankenship GW, Ferriss JA (1997) Lupus associated frosted branch periphlebitis and exudative maculopathy. Retina 17:449–451. doi: 10.1097/00006982-199717050-00016 PubMedGoogle Scholar
  33. 33.
    Karpik AG, Schwartz MM, Dickey LE, Streeten BW, Roberts JL (1985) Ocular immune reactants in patients with systemic lupus erythematosus. Clin Immunol Immunopathol 35:295–312. doi: 10.1016/0090-1229(85)90091-1 PubMedGoogle Scholar
  34. 34.
    Morgan CM, Foster CS, Gragoudas ES (1986) Retinal vasculitis in polyarteritis nodosa. Retina 6:205–209. doi: 10.1097/00006982-198606040-00002 PubMedGoogle Scholar
  35. 35.
    Akova YA, Jabbur NS, Foster CS (1993) Ocular presentation of polyarteritis nodosa. Clinical course and management with steroid and cytotoxic therapy. Ophthalmology 100:1775–1781PubMedGoogle Scholar
  36. 36.
    Curi ALL, Freeman G, Pavesio C (2001) Aggressive retinal vasculitis in polyarteritis nodosa. Eye 15:229–231PubMedGoogle Scholar
  37. 37.
    O’Halloran HS, Pearson PA, Lee WB, Susac JO, Berger JR (1998) Microangiopathy of the brain, retina, and cochlea (Susac syndrome). A report of five cases and a review of the literature. Ophthalmology 105:1038–1044. doi: 10.1016/S0161-6420(98)96005-5 PubMedGoogle Scholar
  38. 38.
    Do TH, Fisch C, Evoy F (2004) Susac syndrome: report of four cases and review of the literature. AJNR Am J Neuroradiol 25:382–388PubMedGoogle Scholar
  39. 39.
    Susac JO, Egan RA, Rennebohm RM, Lubow M (2007) Susac’s syndrome: 1975–2005 microangiopathy/autoimmune endotheliopathy. J Neurol Sci 257:270–272. doi: 10.1016/j.jns.2007.01.036 PubMedGoogle Scholar
  40. 40.
    Martinet N, Fardeau C, Adam R, Bodaghi B, Papo T, Piette JC, Lehoang P (2007) Fluorescein and indocyanine green angiographies in Susac syndrome. Retina 27:1242–1283Google Scholar
  41. 41.
    Theodossiodis P, Kokolakis S, Ladas I, Kollia AC, Chatzonlis D, Theodossiadis G (1995) Retinal vascular involvement in acute toxoplasmic retinochoroiditis. Int Ophthalmol 19:19–24. doi: 10.1007/BF00156414 Google Scholar
  42. 42.
    Ysasaga JE, Davis J (1999) Frosted branch angiitis with ocular toxoplasmosis. Arch Ophthalmol 117:1260–1261PubMedGoogle Scholar
  43. 43.
    Diaz-Valle D, Diaz-Rodriguez E, Diaz-Valle T, Benitez del Castillo JM, Toledano N, Fernandez Acenero MJ (2003) Frosted branch angiitis and late peripheral retinochoroidal scar in a patient with acquired toxoplasmosis. Eur J Ophthalmol 13:726–728PubMedGoogle Scholar
  44. 44.
    Holland GN, Muccioli C, Silveira C, Weisz JM, Belfort R Jr, O’Connor GR (1999) Intraocular inflammatory reactions without focal necrotizing retinochoroiditis in patients with acquired systemic toxoplasmosis. Am J Ophthalmol 128:413–420. doi: 10.1016/S0002-9394(99)00300-1 PubMedGoogle Scholar
  45. 45.
    Ganatra JB, Chandler D, Santos C, Kuppermann B, Margolis TP (2000) Viral causes of the acute retinal necrosis syndrome. Am J Ophthalmol 129:166–172. doi: 10.1016/S0002-9394(99)00316-5 PubMedGoogle Scholar
  46. 46.
    Holland GN (1994) Standard diagnostic criteria for the acute retinal necrosis syndrome. Am J Ophthalmol 117:663–667 Executive Committee of the American Uveitis SocietyPubMedGoogle Scholar
  47. 47.
    Yoser SL, Forster DJ, Rao NA (1993) Systemic viral infections and their retinal and choroidal manifestations. Surv Ophthalmol 37:313–352. doi: 10.1016/0039-6257(93)90064-E PubMedGoogle Scholar
  48. 48.
    Culbertson WW (1989) Infections of the retina in AIDS. Int Ophthalmol Clin 29:108–118. doi: 10.1097/00004397-198902920-00009 PubMedGoogle Scholar
  49. 49.
    Spaide RF, Vitale AT, Toth IR, Oliver JM (1992) Frosted branch angiitis associated with cytomegalovirus retinitis. Am J Ophthalmol 113:522–528PubMedGoogle Scholar
  50. 50.
    Geier SA, Nasemann J, Klauss V, Kronawitter U, Goebel FD (1992) Frosted branch angiitis in a patient with the acquired immunodeficiency syndrome. Am J Ophthalmol 113:203–205PubMedGoogle Scholar
  51. 51.
    Kestelyn P, Lepage P, Van de Perre P (1985) Perivasculitis of the retinal vessels as an important sign in children with AIDS-related complex. Am J Ophthalmol 100:614–615PubMedGoogle Scholar
  52. 52.
    Kestelyn P, Van de Perre P, Rouvroy D, Lepage P, Bogaerts J, Nzaramba D, Clumeck N (1985) A prospective study of the ophthalmologic findings in the acquired immune deficiency syndrome in Africa. Am J Ophthalmol 100:230–238PubMedGoogle Scholar
  53. 53.
    Fine HF, Smith JA, Murante BL, Nussenblatt RB, Robinson MR (2001) Frosted branch angiitis in a child with HIV infection. Am J Ophthalmol 131:394–396. doi: 10.1016/S0002-9394(00)00792-3 PubMedGoogle Scholar
  54. 54.
    Sasaki K, Morooka I, Inomata H, Kashio N, Akamine T, Osame M (1989) Retinal vasculitis in human T-lymphotropic virus type 1 associated myelopathy. Br J Ophthalmol 73:812–815. doi: 10.1136/bjo.73.10.812 PubMedGoogle Scholar
  55. 55.
    Nakao K, Ohba N (1993) Clinical features of HTLV-1 associated uveitis. Br J Ophthalmol 77:274–279. doi: 10.1136/bjo.77.5.274 PubMedGoogle Scholar
  56. 56.
    Nakao K (1996) Ohba N. HTLV-1 associated uveitis revisited: Characteristic grey-white granular deposits on retinal vessels. Br J Ophthalmol 80:719–722. doi: 10.1136/bjo.80.8.719 PubMedGoogle Scholar
  57. 57.
    Nakao K, Ohba N (2003) Human T-cell lymphotropic virus type 1-associated retinal vasculitis in children. Retina 23:197–201. doi: 10.1097/00006982-200304000-00010 PubMedGoogle Scholar
  58. 58.
    Levy-Clarke GA, Buggage RR, Shen D, Vaughen LO, Chan CC, Davis JL (2002) Human T-cell lymphotropic virus-type 1 associated T-cell leukemia/lymphoma masquerading as necrotizing retinal vasculitis. Ophthalmology 109:1717–1722. doi: 10.1016/S0161-6420(02)01132-6 PubMedGoogle Scholar
  59. 59.
    Kincaid J, Schatz H (1983) Bilateral retinal arteritis with multiple aneurysmal dilatations. Retina 3:171–178. doi: 10.1097/00006982-198300330-00005 PubMedGoogle Scholar
  60. 60.
    Chang TS, Aylward W, Davis JL, Mieler WF, Oliver GL, Maberley AL, Gass JD (1995) Idiopathic retinal vasculitis, aneurysms, and neuro-retinitis. Ophthalmology 102:1089–1097PubMedGoogle Scholar
  61. 61.
    Samuel MA, Equi RA, Chang TS, Mieler W, Jampol LM, Hay D, Yannuzzi LA (2007) Idiopathic retinitis, vasculitis, aneurysms, and neuroretinitis (IRVAN): new observations and a proposed staging system. Ophthalmology 114:1526–1529. doi: 10.1016/j.ophtha.2006.11.014 PubMedGoogle Scholar
  62. 62.
    Abu El-Asrar AM, Jestaneiah S, Al-Serhani AM (2004) Regression of aneurysmal dilatations in a case of idiopathic retinal vasculitis, aneurysms and neuroretinitis (IRVAN) associated with allergic fungal sinusitis. Eye 18:197–199. doi: 10.1038/sj.eye.6700554 PubMedGoogle Scholar
  63. 63.
    Owens SL, Gregor ZJ (1992) Vanishing retinal arterial aneurysms: a case report. Br J Ophthalmol 76:637–638. doi: 10.1136/bjo.76.10.637 PubMedGoogle Scholar
  64. 64.
    Sashihara H, Hayashi H, Oshima K (1999) Regression of retinal arterial aneurysms in a case of idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN). Retina 19:250–251PubMedGoogle Scholar
  65. 65.
    Tomita M, Matsubara T, Yamada H, Takahashi K, Nishimura T, Sho K, Uyama M, Matsumura M (2004) Long term follow up in a case of successfully treated idiopathic retinal vasculitis, aneurysms, and neuroretinitis. Br J Ophthalmol 88:302–303. doi: 10.1136/bjo.2003.023002 PubMedGoogle Scholar
  66. 66.
    Rothova A, Lardenoye C (1998) Arterial macroaneurysms in peripheral multifocal chorioretinitis associated with sarcoidosis. Ophthalmology 105:1393–1397. doi: 10.1016/S0161-6420(98)98018-6 PubMedGoogle Scholar
  67. 67.
    Verougstraete C, Snyers B, Leys A, Caspers-Velu LE (2001) Multiple arterial ectasias in patients with sarcoidosis and uveitis. Am J Ophthalmol 131:223–231. doi: 10.1016/S0002-9394(00)00786-8 PubMedGoogle Scholar
  68. 68.
    Yamanaka E, Ohguro N, Nubota A, Yamamoto S, Nakagawa Y, Tano Y (2004) Features of retinal arterial macroaneurysms in patients with uveitis. Br J Ophthalmol 88:884–886. doi: 10.1136/bjo.2003.035923 PubMedGoogle Scholar
  69. 69.
    Ito Y, Nakano M, Kyu N, Takeuchi M (1976) Frosted branch angiitis in a child. Jpn J Clin Ophthalmol 30:797–803Google Scholar
  70. 70.
    Kleiner RC, Kaplan HJ, Shakin JL, Yannuzzi LA, Crosswell HH Jr, McLean WC Jr (1988) Acute frosted retinal periphlebitis. Am J Ophthalmol 106:27–34. doi: 10.1016/0002-9394(88)90365-0 PubMedGoogle Scholar
  71. 71.
    Kleiner RC (1997) Frosted branch angiitis: clinical syndrome or clinical sign? Retina 17:370–371PubMedGoogle Scholar
  72. 72.
    Sykes SO, Horton JC (1997) Steroid-responsive retinal vasculitis with a frosted branch appearance in Crohn’s disease. Retina 17:451–454. doi: 10.1097/00006982-199717050-00017 PubMedGoogle Scholar
  73. 73.
    Markomichelakis NN, Barampouti F, Zafirakis P, Chalkiadakis I, Kouris T, Ekonomopoulos N (1999) Retinal vasculitis with a frosted branch angiitis-like response due to herpes simplex virus type 2. Retina 19:455–457. doi: 10.1097/00006982-199919050-00019 PubMedGoogle Scholar
  74. 74.
    Farrardo J, Fonollosa A, Segura A, Garcia-Arumi J (2008) Frosted branch angiitis associated with Epstein-Barr virus systemic infection. Ocul Immunol Inflamm 16:41–43. doi: 10.1080/09273940701799114 Google Scholar
  75. 75.
    Sugin SL, Henderly DE, Friedman SM, Jampol LM, Doyle JW (1991) Unilateral frosted branch angiitis. Am J Ophthalmol 111:682–685PubMedGoogle Scholar
  76. 76.
    Borkowski LM, Jampol LM (1999) Frosted branch angiitis complicated by retinal neovascularization. Retina 19:454–455. doi: 10.1097/00006982-199919050-00018 PubMedGoogle Scholar
  77. 77.
    Helm CJ, Holland GN (1993) Ocular tuberculosis. Surv Ophthalmol 38:229–256. doi: 10.1016/0039-6257(93)90076-J PubMedGoogle Scholar
  78. 78.
    Rosen PH, Spalton DJ, Graham EM (1990) Intraocular tuberculosis. Eye 4:486–492PubMedGoogle Scholar
  79. 79.
    Gupta A, Gupta V, Arora S, Dogra MR, Bambery R (2001) PCR-positive tubercular retinal vasculitis. Clinical characteristics and management. Retina 21:435–444. doi: 10.1097/00006982-200110000-00004 PubMedGoogle Scholar
  80. 80.
    Biswas J, Sharma T, Gopal L, Madhavan HN, Sulochana KN, Ramakrishnan S (2002) Eales’ disease—an update. Surv Ophthalmol 47:197–214. doi: 10.1016/S0039-6257(02)00288-6 PubMedGoogle Scholar
  81. 81.
    International Study Group for Behçet’s Disease (1990) Criteria for diagnosis of Behçet’s disease. Lancet 335:1078–1080Google Scholar
  82. 82.
    Verity DH, Wallace GR, Vaughan RW, Stanford MR (2003) Behçet’s disease: from Hippocrates to the third millennium. Br J Ophthalmol 87:1175–1183. doi: 10.1136/bjo.87.9.1175 PubMedGoogle Scholar
  83. 83.
    Lim JI, Tessler HH, Goodwin JA (1991) Anterior granulomatous uveitis in patients with multiple sclerosis. Ophthalmology 98:142–145PubMedGoogle Scholar
  84. 84.
    Graham EM, Francis DA, Sanders MD, Rudge P (1989) Ocular inflammatory changes in established multiple sclerosis. J Neurol Neurosurg Psychiatry 52:1360–1363. doi: 10.1136/jnnp.52.12.1360 PubMedGoogle Scholar
  85. 85.
    Engell T, Andersen PK (1982) The frequency of periphlebitis retinae in multiple sclerosis. Acta Neurol Scand 65:601–608PubMedGoogle Scholar
  86. 86.
    Birch MK, Barbosa S, Blumhardt LD, O’Brien C, Harding SP (1996) Retinal venous sheathing and the blood-retinal barrier in multiple sclerosis. Arch Ophthalmol 114:34–39PubMedGoogle Scholar
  87. 87.
    Rucker CW (1972) Sheathing of the retinal veins in multiple sclerosis; review of pertinent literature. Mayo Clin Proc 47:335–340PubMedGoogle Scholar
  88. 88.
    Prineas JW, Wright RG (1978) Macrophages, lymphocytes, and plasma cells in the perivascular compartment in chronic multiple sclerosis. Lab Investig 38:409–421PubMedGoogle Scholar
  89. 89.
    Towler HM, Lightman S (2000) Symptomatic intraocular inflammation in multiple sclerosis. Clin Exp Ophthalmol 28:97–102. doi: 10.1046/j.1442-9071.2000.00270.x Google Scholar
  90. 90.
    Rothova A (2000) Ocular involvement in sarcoidosis. Br J Ophthalmol 84:110–116. doi: 10.1136/bjo.84.1.110 PubMedGoogle Scholar
  91. 91.
    Jones NP (2002) Sarcoidosis. Curr Opin Ophthalmol 13:393–396. doi: 10.1097/00055735-200212000-00009 PubMedGoogle Scholar
  92. 92.
    DeRosa AJ, Margo CE, Orlick ME (1995) Hemorrhagic retinopathy as the presenting manifestation of sarcoidosis. Retina 15:422–427PubMedGoogle Scholar
  93. 93.
    Ohara K, Okubo A, Saski H (1995) Branch retinal vein occlusion in a child with ocular sarcoidosis. Am J Ophthalmol 119:806–807PubMedGoogle Scholar
  94. 94.
    Kimmel AS, McCarthy MJ, Blodi CF, Folk JC (1989) Branch retinal vein occlusion in sarcoidosis. Am J Ophthalmol 107:561–562PubMedGoogle Scholar
  95. 95.
    Duker JS, Brown GC, McNamara JA (1988) Proliferative sarcoid retinopathy. Ophthalmology 95:1680–1686PubMedGoogle Scholar
  96. 96.
    Siam AL, Meegan JM, Gharbawi KF (1980) Rift Valley fever ocular manifestations: observations during the 1977 epidemic in Egypt. Br J Ophthalmol 64:366–374. doi: 10.1136/bjo.64.5.366 PubMedGoogle Scholar
  97. 97.
    Al-Hazmi A, Al-Rajhi AA, Abboud EB, Agaola EA, Al-Hazmi M, Saadi R, Ahmed N (2005) Ocular complications of Rift Valley fever outbreak in Saudi Arabia. Ophthalmology 112:313–318. doi: 10.1016/j.ophtha.2004.09.018 PubMedGoogle Scholar
  98. 98.
    Kaiser PK, Lee MS, Martin DA (2003) Occlusive vasculitis in a patient with concomitant West Nile virus infection. Am J Ophthalmol 136:928–930. doi: 10.1016/S0002-9394(03)00866-3 PubMedGoogle Scholar
  99. 99.
    Chan CK, Limstrom SA, Tarasewicz DG, Lin SG (2006) Ocular features of West Nile virus infection in North America: a study of 14 eyes. Ophthalmology 113:1539–1546. doi: 10.1016/j.ophtha.2006.04.021 PubMedGoogle Scholar
  100. 100.
    Teitelbaum BA, Newman TL, Tresley DJ (2007) Occlusive retinal vasculitis in a patient with West Nile virus. Clin Exp Optom 90:463–467. doi: 10.1111/j.1444-0938.2007.00140.x PubMedGoogle Scholar
  101. 101.
    Herbort CP, Cimino L, Abu El-Asrar AM (2005) Ocular vasculitis: a multidisciplinary approach. Curr Opin Rheumatol 17:25–33. doi: 10.1097/01.bor.0000149083.16639.7e PubMedGoogle Scholar
  102. 102.
    Metha S (2002) Role of computed chest tomography (CT scan) in tuberculous retinal vasculitis. Ocul Immunol Inflamm 10:151–155. doi: 10.1076/ocii. Google Scholar
  103. 103.
    Lee SS, Liu YC, Chen YS, Tsai HC, Wann SR, Lin HH (2008) Comparison of interferon-gamma release assay and the tuberculin skin test for contact investigation of tuberculosis in BCG-vaccinated health care workers. Scand J Infect Dis 40:373–380. doi: 10.1080/00365540701730743 PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media B.V. 2009

Authors and Affiliations

  • Ahmed M. Abu El-Asrar
    • 1
    • 5
    Email author
  • Carl P. Herbort
    • 2
    • 3
  • Khalid F. Tabbara
    • 4
  1. 1.Department of Ophthalmology, College of MedicineKing Saud UniversityRiyadhSaudi Arabia
  2. 2.Inflammatory and Retinal Eye Diseases, Centre for Ophthalmic Specialised CareLausanneSwitzerland
  3. 3.University of LausanneLausanneSwitzerland
  4. 4.The Eye Center and The Eye Foundation for Research in OphthalmologyRiyadhSaudi Arabia
  5. 5.Department of OphthalmologyKing Abdulaziz University HospitalRiyadhSaudi Arabia

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