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Outcome of primary adult optical penetrating keratoplasty with imported donor corneas

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Abstract

Purpose To evaluate the outcome of primary adult optical penetrating keratoplasty (PKP) performed with internationally acquired donor tissue. Patients and methods A retrospective review was performed of the medical records of every patient 12 years of age or older who underwent PKP for keratoconus, corneal edema, stromal scarring, or stromal dystrophy at King Khaled Eye Specialist Hospital in the Kingdom of Saudi Arabia between January 1, 1997 and December 31, 2001, and for whom a minimum of 3 months’ follow-up was available. Results Of 885 eyes that met the inclusion criteria, there were 453 eyes with keratoconus, 180 eyes with corneal edema, 171 eyes with stromal scarring, and 81 eyes with stromal dystrophy. For the entire group, the probability of graft survival was 96.9% at 1 year, 86.0% at 3 years, and 80.3% at 5 years. The 5-year probability of graft survival was 96.2% for keratoconus, 39.4% for corneal edema, 71.1% for stromal scarring, and 85.2% for stromal dystrophy. Increasing donor age was significantly associated with an increased risk of graft failure on multivariate Cox proportional hazard regression analysis (P = 0.005). Endothelial cell density, death-to-preservation time, and preservation-to-surgery time were not significantly associated with an increased risk of graft failure. Conclusions In our patient population, excellent graft survival was achieved utilizing internationally acquired donor tissue for eyes with keratoconus, stromal dystrophy, and stromal scarring, but not for those with corneal edema.

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Author information

Authors and Affiliations

  1. Department of Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia

    Michael D. Wagoner, El-Sayed Gonnah & Abdul-Elah Al-Towerki

  2. Department of Ophthalmology and Visual Sciences, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA, 52246, USA

    Michael D. Wagoner

  3. Department of Ophthalmology, Faculty of Health Sciences, University of Stellenbosch, Stellenbosch, Republic of South Africa

    Michael D. Wagoner

Authors
  1. Michael D. Wagoner
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  2. El-Sayed Gonnah
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  3. Abdul-Elah Al-Towerki
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The King Khaled Eye Specialist Hospital Cornea Transplant Study Group

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Correspondence to Michael D. Wagoner.

Additional information

The staff members of the King Khaled Eye Specialist Hospital Cornea Transplant Study Group are given in the Appendix.

Appendix

Appendix

The King Khaled Eye Specialist Hospital Cornea Transplant Study Group

Physician Members (KKESH): Klaus D. Teichmann, MD; Abdul-Elah Al-Towerki, MD; Michael D. Wagoner, MD

Physician Members (External Consultants): Kenneth M. Goins, MD; Anna S. Kitzmann, MD; John E. Sutphin, MD

Data Coordination Staff: Barbara Elias, CEBT; El-Sayed Gonnah, CEBT; Jamila Al-Shahrani, BSC

Biostatistician: M. Bridgett Zimmerman, PhD

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Wagoner, M.D., Gonnah, ES., Al-Towerki, AE. et al. Outcome of primary adult optical penetrating keratoplasty with imported donor corneas. Int Ophthalmol 30, 127–136 (2010). https://doi.org/10.1007/s10792-009-9295-x

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