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Fusarium keratitis and endophthalmitis associated with lens contact wear

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Abstract

IntroductionFusarium keratitis is a severe corneal infection that is usually seen in tropical and subtropical countries after a corneal trauma. In 2005–2006, an epidemic of Fusarium keratitis, occurring predominantly among contact lens wearers, was observed in several countries. Case report We describe the clinical course of a Fusarium keratitis which failed to respond to systemic and local voriconazole treatment, and experienced a progression to a severe keratitis with endophthalmitis, requiring early therapeutic keratoplasty (“à chaud”). After 8 months of follow up, the vision recovered to 20/50. Discussion After the 2005–2006 worldwide epidemics, case–control studies pointed out that a new lens care solution, ReNu with MoistureLoc® (Bausch & Lomb™), was likely responsible of numerous cases. Complementary studies underlined that this infection mostly concerned non-compliant patients, i.e., those reusing the solution several times, since this results in a decrease of the antifungal activity due to the uptake of the biguanides into the lens. ConclusionFusarium endophtalmitis can result in a devastating disease with a poor visual outcome. An initial antifungal dual therapy may control the infection. In case of failure, an early keratoplasty may be mandatory. For contact lens wearers, education on sanitary good practice is necessary to avoid new epidemics in the future.

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Acknowledgments

Thanks to Dr Antoine Labbe and to Miss Beatrice Dupas for imaging with the confocal microscopy HRTII (Quinze-Vingts National Center of Ophthalmology, Department of Ophthalmology III, Christophe Baudouin).

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Authors and Affiliations

  1. Department of Ophthalmology, Bicêtre University Hospital, APHP, University Paris XI, Le Kremlin Bicêtre, Paris, France

    Julia Proença-Pina, Isabelle Ssi Yan Kai, Hervé Offret & Marc Labetoulle

  2. Ophthalmology Department, Strasbourg University Hospital, Strasbourg, France

    Tristan Bourcier

  3. Department of Pathology, Bicêtre University Hospital, APHP, University Paris XI, Le Kremlin Bicêtre, Paris, France

    Monique Fabre

  4. CHU de Bicêtre, 78 rue du Général Leclerc, Le Kremlin Bicêtre CEDEX, 94275, Paris, France

    Marc Labetoulle

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  1. Julia Proença-Pina
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  2. Isabelle Ssi Yan Kai
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Correspondence to Marc Labetoulle.

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Proença-Pina, J., Ssi Yan Kai, I., Bourcier, T. et al. Fusarium keratitis and endophthalmitis associated with lens contact wear. Int Ophthalmol 30, 103–107 (2010). https://doi.org/10.1007/s10792-008-9290-7

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