Skip to main content

Advertisement

SpringerLink
Log in

Latanoprost-induced changes in the iris and trabeculum: an electron-microscopic morphological study

  • Case Report
  • Published:
International Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose The purpose was to analyze the histological aspects of irises and trabeculums by transmission electron microscopy (TEM) in patients who had or had not received latanoprost therapy. Materials and methods Seven patients with pseudoexfoliation glaucoma were enrolled in the study. Four of them had been using latanoprost monotheraphy for 2 months. Iris samples were obtained by peripheral iridectomy. Trabeculum samples were obtained during the trabeculectomy without use of antimetabolites. The specimens were further processed for transmission electron microscopy. Results There was extracellular pigmentation in the iris stroma in four patients treated with latanoprost, whereas in the control group there was no free melanin in the stroma. Intracellular pigment in fibroblasts, melanocytes, or both was present in all samples in the study group. More pigment accumulation was found in the trabecular endothelial cells of the patients who had received latanoprost therapy. Conclusion Latanoprost therapy causes pigment accumulation in the iris and trabeculum of patients in short-term therapy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

References

  1. Vesti E, Kivela T (2000) Exfoliation syndrome and exfoliation glaucoma. Prog Retin Eye Res 19:345–368

    Article  CAS  PubMed  Google Scholar 

  2. Morrison JC, Green WR (1988) Light microscopy of the exfoliation syndrome. Acta Ophthalmol (Copenh) 184:15–27

    Google Scholar 

  3. Kuchle M, Schlötzer-Schrehardt U, Naumann GO (1991) Occurrence of pseudoexfoliative material in parabulbar structures in pseudoexfoliation syndrome. Acta Ophthalmol (Copenh) 69:124–130

    Article  CAS  Google Scholar 

  4. Ringvold A (1973) On the occurrence of pseudo-exfoliation material in extrabulbar tissue from patients with pseudo-exfoliation syndrome of the eye. Acta Ophthalmol (Copenh) 51:411–418

    Article  CAS  Google Scholar 

  5. Schlötzer-Schrehardt U, Koca MR, Naumann GO, Volkholz H (1992) Pseudoexfoliation syndrome. Ocular manifestation of a systemic disorder. Arch Ophthalmol 110:1952–1956

    Google Scholar 

  6. Camras CB, Alm A, Watson P, Stjernschantz J (1996) Latanoprost, a prostaglandin analog, for glaucoma therapy. Efficacy and safety after one year of treatment in 198 patients. Latanoprost Study Groups. Ophthalmology 103:1916–1924

    CAS  PubMed  Google Scholar 

  7. Yamamoto T, Kitazawa Y (1997) Iris-color change developed after topical isopropyl unoprostone treatment. J Glaucoma 6:430–432

    Article  CAS  PubMed  Google Scholar 

  8. Goldberg I, Cunha-Vaz J, Jakobsen JE, Nordmann JP, Trost E, Sullivan EK (2001) Comparison of topical travoprost eye drops given once daily and timolol 0.5% given twice daily in patients with openangle glaucoma or ocular hypertension. J Glaucoma 10:414–422

    Article  CAS  PubMed  Google Scholar 

  9. Sherwood M, Brandt J (2001) Six-month comparison of bimatoprost once-daily and twice-daily with timolol twice-daily in patients with elevated intraocular pressure. Surv Ophthalmol 45:S361–S368

    Article  PubMed  Google Scholar 

  10. Puska P (1996) The amount of lens exfoliation and chamber-angle pigmentation in exfoliation syndrome with or without glaucoma. Acta Ophthalmol Scand 74:202–204

    Article  Google Scholar 

  11. Schlotzer-Schrehardt U, Naumann GO (1995) Trabecular meshwork in pseudoexfoliation syndrome with and without open-angle glaucoma. A morphometric, ultrastructural study. Invest Ophthalmol Vis Sci 36:1750–1764

    CAS  PubMed  Google Scholar 

  12. Gottanka J, Flugel-Koch C, Martus P, Johnson DH, Lutjen-Drecoll E (1997) Correlation of pseudoexfoliative material and optic nerve damage in pseudoexfoliation syndrome. Invest Ophthalmol Vis Sci 38:2435–2446

    CAS  PubMed  Google Scholar 

  13. Kuchle M, Amberg A, Martus P, Nguyen NX, Naumann GO (1997) Pseudoexfoliation syndrome and secondary cataract. Br J Ophthalmol 81:862–866

    Article  CAS  PubMed  Google Scholar 

  14. Morrison JC, Green WR (1988) Light microscopy of the exfoliation syndrome. Acta Ophthalmol Suppl 184:5–27

    Article  CAS  PubMed  Google Scholar 

  15. Alm A, Stjernschantz J (1995) Effects on intraocular pressure and side effects of 0.005% latanoprost applied once daily, evening or morning. A comparison with timolol. Scandinavian Latanoprost Study Group. Ophthalmology 102:1743–1752

    CAS  PubMed  Google Scholar 

  16. Camras CB, Neely DG, Weiss EL (2000) Latanoprost-induced iris color darkening: a case report with long-term follow-up. J Glaucoma 9:95–98

    CAS  PubMed  Google Scholar 

  17. Cantor LB (2001) Bimatoprost: a member of a new class of agents, the prostamides, for glaucoma management. Expert Opin Investig Drugs 10:721–731

    Article  CAS  PubMed  Google Scholar 

  18. Stjernschantz JW, Albert DM, Hu DN, Drago F, Wistrand PJ (2002) Mechanism and clinical significance of prostaglandin-induced iris pigmentation. Surv Ophthalmol 47:162–175

    Article  Google Scholar 

  19. Stjernschantz J, Ocklind A, Wentzel P, Lake S, Hu DN (2000) Latanoprost-induced increase of tyrosinase transcription in iridial melanocytes. Acta Ophthalmol Scand 78:618–622

    Article  CAS  PubMed  Google Scholar 

  20. Drago F, Marino A, La Manna C (1999) Alpha-Methyl-p-tyrosine inhibits latanoprost-induced melanogenesis in vitro. Exp Eye Res 68:85–90

    Article  CAS  PubMed  Google Scholar 

  21. Pfeiffer N, Grierson I, Goldsmith H, Hochgesand D, Winkgen-Bohres A, Appleton P (2001) Histological effects in the iris after 3 months of latanoprost therapy: the Mainz 1 study. Arch Ophthalmol 119:191–196

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Ophthalmology, Eskisehir Osmangazi University Faculty of Medicine, Meselik, Eskisehir, Turkey

    Nilgun Yildirim, Afsun Sahin & Selcuk Kara

  2. Department of Histology and Embryology, Eskisehir Osmangazi University Faculty of Medicine, Meselik, Eskisehir, Turkey

    Cengiz Baycu

Authors
  1. Nilgun Yildirim
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Afsun Sahin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Selcuk Kara
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Cengiz Baycu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Nilgun Yildirim.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yildirim, N., Sahin, A., Kara, S. et al. Latanoprost-induced changes in the iris and trabeculum: an electron-microscopic morphological study. Int Ophthalmol 30, 93–97 (2010). https://doi.org/10.1007/s10792-008-9285-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10792-008-9285-4

Keywords

Search

Navigation