Skip to main content

Trends in penetrating keratoplasty in the United States 1980–2005

Abstract

In this review, we analyze the trends in corneal transplantation over the past 25 years in the United States. The most dramatic change was the progressive sharp increase in the number of corneal transplants performed during the 1980s, corresponding with the rise of pseudophakic bullous keratopathy (PBK) as the leading indication for keratoplasty. More recently, there has been a steady annual decline in total keratoplasties for more than a decade, corresponding with a decline in the cases performed for PBK, which still accounts for the highest percentage of cases done. Regrafts have been an increasingly important indication for keratoplasty, as older grafts fail. Keratoconus, Fuchs dystrophy, and other inherited diseases have remained consistent indications for keratoplasty during the last quarter century.

This is a preview of subscription content, access via your institution.

Fig. 1
Fig. 2

References

  1. Smith RE, McDonald HR, Nesburn AB, Minckler DS (1980) Penetrating keratoplasty: changing indications, 1947 to 1978. Arch Ophthalmol 98(7):1226–1229

    PubMed  CAS  Google Scholar 

  2. Arentsen JJ, Morgan B, Green WR (1976) Changing indications for keratoplasty. Am J Ophthalmol 81(3):313–318

    PubMed  CAS  Google Scholar 

  3. Brady SE, Rapuano CJ, Arentsen JJ, Cohen EJ, Laibson PR (1989) Clinical indications for and procedures associated with penetrating keratoplasty, 1983–1988. Am J Ophthalmol 108(2):118–122

    PubMed  CAS  Google Scholar 

  4. Hyman L, Wittpenn J, Yang C (1992) Indications and techniques of penetrating keratoplasties, 1985–1988. Cornea 11(6):573–576

    PubMed  Article  CAS  Google Scholar 

  5. Mamalis N, Anderson CW, Kreisler KR, Lundergan MK, Olson RJ (1992) Changing trends in the indications for penetrating keratoplasty. Arch Ophthalmol 110(10):1409–1411

    PubMed  CAS  Google Scholar 

  6. Lindquist TD, McGlothlan JS, Rothkis WM, Chandler JW (1991) Indications for penetrating keratoplasty:1980–1988. Cornea 10(3):210–216

    PubMed  Article  CAS  Google Scholar 

  7. Worthen DM, Boucher JA, Buxton J, Lowther G, Talbott M (1981) Update report on intraocular lenses. Update report on intraocular lenses. Ophtha 88(5):381–385

    CAS  Google Scholar 

  8. Stark WJ, Worthen DM, Holladay JT, Bath PE, Jacobs ME, Murray GC, McGhee ET, Talbott MW, Shipp MD, Thomas NE et al. (1984) The FDA report on intraocular lenses. Aust J Ophthalmol 12(1):61–69

    PubMed  Article  CAS  Google Scholar 

  9. Waring GO (1989) The 50-year epidemic of pseudophakic bullous edema. Arch Ophthalmol 107(5):657–659

    PubMed  Google Scholar 

  10. Lois N, Kowal VO, Cohen EJ, Rapuano CJ, Gault JA, Raber IM, Laibson PR (1997) Indications for penetrating keratoplasty and associated procedures, 1989–1995. Cornea 16(6):623–629

    PubMed  Article  CAS  Google Scholar 

  11. Flowers CW, Chang KY, McLeod SD, Irvine JA, McDonnell PJ, Rao N, Smith RE (1995) Changing indications for penetrating keratoplasty, 1989–1993. Cornea 14(6):583–588

    PubMed  Article  CAS  Google Scholar 

  12. Barron BA, Gee L, Hauck WW, Kurinij N, Dawson CR, Jones DB, Wilhelmus KR, Kaufman HE, Sugar J, Hyndiuk RA et al. (1994) A controlled trial of oral acyclovir for herpes simplex stromal keratitis. Ophthalmology 101:1871–1882

    PubMed  CAS  Google Scholar 

  13. Cosar CB, Sridhar MS, Cohen EJ, Held EL, Alvim P de T, Rapuano CJ, Raber IM, Laibson PR (2002) Indications for penetrating keratoplasty and associated procedures, 1996–2000. Cornea 21(2):148–151

  14. Sugar A, Sugar J (2000) Techniques in penetrating keratoplasty: a quarter century of development. Cornea 19(5):603–610

    PubMed  Article  CAS  Google Scholar 

  15. Dobbins KR, Price FW Jr, Whitson WE (2000) Trends in the indications for penetrating keratoplasty in the midwestern United States. Cornea 19(6):813–816

    PubMed  Article  CAS  Google Scholar 

  16. Kang PC, Klintworth GK, Kim T, Carlson AN, Adelman R, Stinnett S, Afshari NA (2005) Trends in the indications for penetrating keratoplasty, 1980–2001. Cornea 24(7):801–803

    PubMed  Article  Google Scholar 

  17. Rapuano CJ (2001) Excimer laser phototherapeutic keratectomy. Curr Opin Ophthalmol 12:288–293

    PubMed  Article  CAS  Google Scholar 

  18. Darlington JK, Adrean SD and Schwab IR (2006) Trends in penetrating keratoplasty in the United States from 1980 to 2004. Ophthalmology 113(12):2171–2175

    Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Christopher J. Rapuano.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Ghosheh, F.R., Cremona, F.A., Rapuano, C.J. et al. Trends in penetrating keratoplasty in the United States 1980–2005. Int Ophthalmol 28, 147–153 (2008). https://doi.org/10.1007/s10792-007-9177-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10792-007-9177-z

Keywords

  • Corneal transplantation
  • Keratoplasty
  • Pseudophakic bullous keratopathy
  • Twenty-five-year trends
  • United States