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Prophylactic use of timolol maleate to prevent intraocular pressure elevation after Nd-YAG laser posterior capsulotomy

International Ophthalmology volume 28, pages 19–22 (2008)Cite this article

Abstract

Purpose

To evaluate the effective prophylaxis of topical 0.5% timolol maleate for the intraocular pressure rise following Nd-YAG laser posterior capsulotomy.

Methods

A total of 190 eyes of 184 patients who underwent Nd-YAG laser posterior capsulotomy were randomly assigned to pre-treatment with either topical application of 0.5% timolol maleate (treatment group) or nothing (control group).

Results

The mean intraocular pressure (IOP) of the treatment group was 14.8 ± 3.0 mmHg before capsulotomy and 15.7 ± 3.4 mmHg after capsulotomy (P > 0.05), whereas IOP was 15.1 ± 3.3 mmHg and 17. 2 ± 4.3 mmHg (P < 0.05) for the control group. There was no statistically significant difference between the two groups with regard to mean IOP before capsulotomy (P > 0.05), but a statistically significant difference was seen between the two groups after capsulotomy (P < 0.05). Six of 91 eyes (6.6%, two with aphakia) in the treatment group had an IOP elevation greater than 6 mmHg compared with 14 of 99 eyes (14.1%, eight with aphakia) in the control group (P < 0.01).

Conclusion

Pre-treatment with a topical application of 0.5% timolol maleate is effective in preventing IOP elevation after Nd-YAG laser posterior capsulotomy.

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Affiliations

  1. Department of Ophthalmology, Second Affiliated Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai, 200003, China

    Ji-Ping Cai, Jin-Wei Cheng, Rui-Li Wei, Xiao-Ye Ma, Feng Jiang, Huang Zhu & You Li

Authors
  1. Ji-Ping Cai
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  2. Jin-Wei Cheng
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  3. Rui-Li Wei
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  4. Xiao-Ye Ma
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  5. Feng Jiang
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  6. Huang Zhu
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  7. You Li
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Correspondence to Ji-Ping Cai.

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Cai, JP., Cheng, JW., Wei, RL. et al. Prophylactic use of timolol maleate to prevent intraocular pressure elevation after Nd-YAG laser posterior capsulotomy. Int Ophthalmol 28, 19–22 (2008). https://doi.org/10.1007/s10792-007-9101-6

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  • DOI: https://doi.org/10.1007/s10792-007-9101-6

Keywords

  • Nd-YAG laser
  • Posterior capsulotomy
  • Intraocular pressure
  • Timolol maleate