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Interobserver variability in confocal optic nerve analysis (HRT)

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Abstract

Background/aims To study the observer-related variability of optic nerve head (ONH) measurements using confocal laser scanning tomography (HRT I) in a screening setting.

Methods Six experienced glaucoma specialists independently evaluated 50 ONH topographies from 25 adults using HRT software ver. 2.01 in a masked fashion. ONH topographies were obtained from a cohort study of 882 healthy adults and additionally included one patient with glaucomatous eyes. A glaucoma-screening-like setting was intended. The mean interobserver difference was defined as the mean percentual difference between an observer’s analysis and the mean of all six observers for all eyes and all observers. The interobserver range was calculated for each eye as the percentual difference between the lowest and highest measurement, with the highest measurement as denominator. Additionally, Kendall’s coefficient of rank concordance was assessed for the main HRT parameters.

Results Mean disc area ranged from 1.83 ± 0.49 to 2.21 ± 0.40 mm² (mean interobserver difference: 8.3%; interobserver range: 5–50%; rank concordance: 0.86). The lowest mean interobserver differences were found for mean retinal nerve fibre layer thickness (RNFLT; 6.5%), maximum cup depth (2.9%) and cup shape (6.8%). An increased interobserver range was significantly correlated to a low cup to disc area ratio (r = 0.64, P < 0.0001).

Conclusions The observer-dependent diagnostic variability of HRT measurements can lead to divergent diagnostic evaluation of the ONH in a screening setting. Any HRT software relying on a reference database is exposed to relevant observer-related variability of the disc area. For screening purposes, HRT measurements should be completed by other diagnostic methods to compensate for possible diagnostic uncertainty.

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Acknowledgements

This study has been presented in part as poster at the Association for Research in Vision and Ophthalmology (ARVO) 2002 in Fort Lauderdale, Fla., USA.

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Authors and Affiliations

  1. Ophthalmology, University of Cologne, Cologne, Germany

    Manuel M. Hermann, Christian P. Jonescu-Cuypers & Michael Diestelhorst

  2. Glaucoma Research Unit, Moorfields Eye-Hospital, London, UK

    David F. Garway-Heath

  3. Ophthalmology, Eye Hospital, Bielefeld, Germany

    Reinhard O. W. Burk

  4. Ophthalmology, Faculty of Clinical Medicine Mannheim, Ruprecht-Karls-University, Heidelberg, Germany

    Jost B. Jonas

  5. Ophthalmology, University of Erlangen-Nürnberg, Erlangen, Germany

    Christian Y. Mardin

  6. Ophthalmology, Albert-Ludwigs-University of Freiburg, Freiburg, Germany

    Jens Funk

  7. Universitäts-Augenklinik Köln, Joseph-Stelzmann-Str. 9, 50924, Kőln, Germany

    Manuel M. Hermann

Authors
  1. Manuel M. Hermann
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  2. David F. Garway-Heath
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  3. Christian P. Jonescu-Cuypers
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  4. Reinhard O. W. Burk
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  5. Jost B. Jonas
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  6. Christian Y. Mardin
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  7. Jens Funk
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  8. Michael Diestelhorst
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Corresponding author

Correspondence to Manuel M. Hermann.

Additional information

The study was presented in part at the ARVO meeting 2002.

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Hermann, M.M., Garway-Heath, D.F., Jonescu-Cuypers, C.P. et al. Interobserver variability in confocal optic nerve analysis (HRT). Int Ophthalmol 26, 143–149 (2005). https://doi.org/10.1007/s10792-006-9022-9

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  • DOI: https://doi.org/10.1007/s10792-006-9022-9

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