Abstract
Background Retinal vasculitis associated with mixed connective tissue disease (MCTD) has rarely been reported in the literature. We describe a rare case of a patient with serious retinal vasculopathy and vitreous hemorrhages associated with MCTD.
Case A 53-year-old woman with MCTD who has had recurrent retinal vasculitis and vitreous hemorrhage in the right eye since 2000 presented with blurred vision in the right eye in April 2003. The best-corrected visual acuity was counting finger in the right eye. The patient was clinically diagnosed as having retinal and vitreous hemorrhages and retinal infarction. Prednisolone was administered orally in a daily dose of 20 mg.
Results The retinal and vitreous hemorrhage improved in 7 days. The best-corrected visual acuity improved to more than 20/20 on prednisolone alone.
Conclusion MCTD can be associated with retinal vasculitis and vitreous hemorrhage which in our case responded well to systematic low doses of corticosteroid therapy.
Similar content being viewed by others
References
Sharp GC, Irvin WS, Tan EM, Gould RG, Holman HR (1972) Mixed connective tissue disease-an apparently distinct rheumatic disease syndrome associated with a specific antibody to an extractable nuclear antigen (ENA). Am J Med 52:148–59
Dodds EM, Lowder CY, Foster RE (1995) Plasmapheresis treatment of central retinal vein occlusion in a young adult. Am J Ophthalmol 119:519–21
Kraus A, Cervantes G, Barojas E, Alarcon Segovia D (1985) Retinal vasculitis in mixed connective tissue disease. A fluoroangiographic study. J Rheumatol 12:1122–4
Ackerman J, Gonzalez EF, Gilbert-Barness E (1999) Immunological studies of the placenta in maternal connective tissue disease. Pediatr Dev Pathol 2:19–24
Kasp E, Whiston R, Dumonde D, Graham E, Stanford M, Sanders M (1992) Antibody affinity to retinal S-antigen in patients with retinal vasculitis. Am J Ophthalmol 113:697–701
Kasp E, Graham EM, Stanford MR, Sanders MD, Dumonde DC (1989) A point prevalence study of 150 patients with idiopathic retinal vasculitis: 2. Clinical relevance of antiretinal autoimmunity and circulating immune complexes. Br J Ophthalmol 73:722–30
Stanford MR, Graham E, Kasp E, Sanders MD, Dumonde DC (1988) A longitudinal study of clinical and immunological findings in 52 patients with relapsing retinal vasculitis. Br J Ophthalmol 72:442–7
Matsuo T, Nakayama T, Tsuji T, Koyama T, Matsuo N, Koide N (1986) Immunological studies of uveitis. 2. Immune complex containing retinal S antigen in patient with chronic intractable uveitis. Jpn J Ophthalmol 30:480–6
Author information
Authors and Affiliations
Corresponding author
Additional information
The authors have no commercial or proprietary interest in the product or company described in the current article.
Rights and permissions
About this article
Cite this article
Mimura, T., Usui, T., Amano, S. et al. Retinal vasculitis and vitreous hemorrhage associated with mixed connective tissue disease. Int Ophthalmol 26, 159–161 (2005). https://doi.org/10.1007/s10792-006-9015-8
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10792-006-9015-8