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Surgical Excision, Cryotherapy, Autolimbal Transplantation and Mitomycin-C in Treatment of Conjunctival–corneal Intraepithelial Neoplasia

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Abstract

Purpose

To report surgical excision, cryotherapy, autologous conjunctival–limbal transplantation and topical mitomycin C (MMC) in the patient with extensive conjunctival–corneal intraepithelial neoplasia.

Methods

Case report and literature review.

Results

A 75-year-old woman was referred to our department with the diagnosis of conjunctival–corneal neoplasia. Slit-lamp microscopic examination revealed an extensive papilliform tumoral mass invading the limbus at 360-degrees, and bulbar conjunctiva and cornea. Visual acuity was finger counting from 2 m in the right eye and 20/20 in the left eye. We performed total surgical excision, cryotherapy and autologous conjunctival–limbal transplantation in the right eye. Mitomycin-C 0.02% eye drops four times a day were prescribed for 4 weeks after the surgery. After the treatment, the visual acuity increased to 0.7 in the right eye. Corneal epithelium completely healed within 1 week after the surgery. No corneal epithelium-related problem or neoplasia recurrence were noted during the 2-year follow-up period.

Conclusions

This technique may be useful in reconstruction of eyes with extensive neoplastic involvement of the conjunctiva, limbus, and cornea. In addition, mitomycin C drops may be useful in preventing postoperative recurrence of conjunctival–corneal intraepithelial neoplasia.

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Authors and Affiliations

  1. Inonu University Medical Faculty, Turgut Ozal Medical Center, Research Hospital, Malatya, Turkey

    Selim Doganay, Hamdi Er, Ahmet Tasar & Iclal Gürses

  2. Zafer Mah. Gundogdu Cad. Pinar Apt. No: 44/2, TR-44160, Malatya, Turkey

    Selim Doganay

Authors
  1. Selim Doganay
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  2. Hamdi Er
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  3. Ahmet Tasar
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  4. Iclal Gürses
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Correspondence to Selim Doganay.

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Doganay, S., Er, H., Tasar, A. et al. Surgical Excision, Cryotherapy, Autolimbal Transplantation and Mitomycin-C in Treatment of Conjunctival–corneal Intraepithelial Neoplasia. Int Ophthalmol 26, 53–57 (2005). https://doi.org/10.1007/s10792-006-0006-6

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  • DOI: https://doi.org/10.1007/s10792-006-0006-6

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