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The pharmacological properties of the novel peptide BPC 157 (PL-10)

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Abstract

The reported beneficial effects of the gastric mucosal derived pentadecapeptide BPC 157 (Gly Glu Pro Pro Pro Gly Lys Pro Ala Asp Asp Ala Gly Leu Val, M.W. 1419) on different organ lesions are reviewed. Apart from the effects on various gastrointestinal lesions, the potentially beneficial effect on pancreas, liver injuries, endothelium and heart damage, i.e. dysrhythmias following reoxygenation, and blood pressure, along with effect on experimental acute/chronic inflammation, wound and fracture (pseudoarthrosis) healing are described. It appears that these beneficial effects all together provide a particular network reflecting activity of a special peptidergic defence system. In support of this concept, it appears that there are interactions of this pentadecapeptide with many important systems (namely, dopamine-, NO-, prostaglandin-, somatosensory neurone-systems), that could provide a basis for the observed protective effects. Moreover, since disturbance of these systems’ functions (i.e. dopamine-, NO-, somatosensory neuronal-system) which manifest either over-activity or as inhibition, may contribute to the multiple lesions in different organs. The reported evidence that this pentadecapeptide is able to counteract both their over-action, and their inhibition, may suggest this pentadecapeptide as a new, but most probably essential physiological defence system and that should be further investigated.

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  1. Department of Pharmacology, Medical Faculty, University of Zagreb, Salata 11, P.O. Box 916, 10000, HR Zagreb, Croatia

    Predrag Sikiric MD, PhD

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Correspondence to Predrag Sikiric MD, PhD.

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This work under the direction of Prof. Sikiric involved the following authors: Gorana Aralica, Josip Aralica, Gojko Buljat, Valentina Coric, Vedran Coric, Bozidar Duplancic, Miroslav Gjurasin, Zeljko Grabarevic, Miroslav Hanzevacki, Stipislav Jadrijevic, Vjekoslav Jagic, Pasko Konjevoda, Martina Lovric, Anton Marovic, Pavle Miklic, Darko Mikus, Stjepan Mise, Darko Perovic, Marijan Petek, Ivo Rotkvic, Rudolf Rucman, Bozidar Sebecic, Sven Seiwerth, Jadranka Separovic, Zoran Simec, Zoran Slobodnjak, Dinko Stancic-Rokotov, Branko Turkovic, Tomislav Ziger, Ivan Zoricic.

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Sikiric, P. The pharmacological properties of the novel peptide BPC 157 (PL-10). Inflammopharmacol 7, 1–14 (1999). https://doi.org/10.1007/s10787-999-0022-z

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