Abstract
Effects of interleukin-1 (IL-1) blockers, CK130 and CK131, on IL-1-induced uveitis and proliferation of fibroblast-like corneal and conjunctival cells were investigated in this study. It was found that CK130 and CK131 inhibited IL-1-induced uveitis in rat eyes effectively at 3 mg/kg and 10 mg/kg, respectively. Further, CK130 and CK131 inhibited fibroblast-like corneal and conjunctival cell growth effectively at 10–300 µg/ml and 30–300 µg/ml, respectively. It was also found that DNA synthesis was markedly reduced by CK130 and CK131 at 30–100 µg/ml. RNA synthesis was also inhibited by these CK compounds but protein synthesis was little affected or enhanced.
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Xuan, B., Chiou, G.C.Y. Anti-uveitis and inhibition of fibroblast-like corneal and conjunctival cells by interleukin-1 blockers. Inflammopharmacol 6, 119–132 (1998). https://doi.org/10.1007/s10787-998-0029-x
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DOI: https://doi.org/10.1007/s10787-998-0029-x