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Insulin regulates Il-1α, Ifn-y and Il-4 release from murine splenocytes stimulated with staphylococcal protein A, toxic shock syndrome toxin-1 and streptococcal lysin S

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Abstract

In this study, changes were investigated in release of IL-1α, IFN-γ and IL-4 from mouse splenocytes stimulated with staphylococcal protein A (SpA), toxic shock syndrome toxin-1 (TSST-1) or streptococcal lysin S (SLS) in the presence of insulin. The results show that insulin-treated splenocytes stimulated by SpA had a 25% increase in IFN-γ release and a 50% decrease in IL-4 compared with splenocytes treated with SpA alone. IL-1α release was unchanged compared with controls. Insulintreated splenocytes stimulated with TSST-1 had a 30% fall in IL-1α and IFN-γ release compared with controls. There were no changes in IL-4 release. Splenocytes stimulated with SLS after insulin treatment increased their release of IL-1α and IFN-γ by 50%, whereas IL-4 release was unchanged. The data suggest that the insulin may have important functional implications in immunoregulation.

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Authors and Affiliations

  1. Istituto di Microbiologia, Facoltà di Medicina e Chirurgia, Seconda Università degli Studi di Napoli, Italy

    L. Sommese, P. Scarfogliero, M. Vitiello & F. Gorga

  2. Dipartimento di Patologia, Profilassi ed Ispezione degli Alimenti, Sezione di Malattie Infettive, Facoltà di Veterinaria, Università degli Studi di Napoli, Federico II, Italy

    M. Galdiero

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  1. L. Sommese
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  2. P. Scarfogliero
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  3. M. Vitiello
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  4. F. Gorga
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  5. M. Galdiero
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Sommese, L., Scarfogliero, P., Vitiello, M. et al. Insulin regulates Il-1α, Ifn-y and Il-4 release from murine splenocytes stimulated with staphylococcal protein A, toxic shock syndrome toxin-1 and streptococcal lysin S. Inflammopharmacol 6, 311–320 (1998). https://doi.org/10.1007/s10787-998-0015-3

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  • DOI: https://doi.org/10.1007/s10787-998-0015-3

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