Abstract
A comment to: Ghaleh HEG, Izadi M, Javanbakht M, Ghanei M, Einollahi B, Jafari NJ, Alishiri G, Aslani J, Abolghasemi H, Simonetti V, Khafaei M, Zhao S, Saadat SH, Ahmadi M, Parvin S, Vazifedoust S, Alvanagh AG. Cytokine profile and antioxidants status in the moderate and severe COVID-19 patients: a trial of ozone therapy impact as a medicinal supplement. Inflammopharmacology. 2023 Jul 12. https://doi.org/10.1007/s10787-023-01288-9.
Data availability
Enquiries about data availability should be directed to the authors.
References
Carlini V, Noonan DM, Abdalalem E, Goletti D, Sansone C, Calabrone L, Albini A (2023) The multifaceted nature of IL-10: regulation, role in immunological homeostasis and its relevance to cancer, COVID-19 and post-COVID conditions. Front Immunol 8(14):1161067
Chirumbolo S, Valdenassi L, Simonetti V, Bertossi D, Ricevuti G, Franzini M, Pandolfi S (2021) Insights on the mechanisms of action of ozone in the medical therapy against COVID-19. Int Immunopharmacol 96:107777
Fernández-Cuadros ME, Albaladejo-Florín MJ, Peña-Lora D, Álava-Rabasa S, Pérez-Moro OS (2020) Ozone (O3) and SARS-CoV-2: Physiological bases and their therapeutic possibilities according to COVID-19 evolutionary stage. SN Compr Clin Med 2(8):1094–1102
Franzini M, Valdenassi L, Ricevuti G, Chirumbolo S, Depfenhart M, Bertossi D, Tirelli U (2020) Oxygen-ozone (O2–O3) immunoceutical therapy for patients with COVID-19. Preliminary Evidence Reported Int Immunopharmacol 88:106879
Ghaleh HEG, Izadi M, Javanbakht M, Ghanei M, Einollahi B, Jafari NJ, Alishiri G, Aslani J, Abolghasemi H, Simonetti V, Khafaei M, Zhao S, Saadat SH, Ahmadi M, Parvin S, Vazifedoust S, Alvanagh AG (2023) Cytokine profile and antioxidants status in the moderate and severe COVID-19 patients: a trial of ozone therapy impact as a medicinal supplement. Inflammopharmacology. https://doi.org/10.1007/s10787-023-01288-9
Han H, Ma Q, Li C, Liu R, Zhao L, Wang W, Zhang P, Liu X, Gao G, Liu F, Jiang Y, Cheng X, Zhu C, Xia Y (2020) Profiling serum cytokines in COVID-19 patients reveals IL-6 and IL-10 are disease severity predictors. Emerg Microbes Infect 9(1):1123–1130
Hernández A, Viñals M, Isidoro T, Vilás F (2020) Potential Role of Oxygen-Ozone Therapy in Treatment of COVID-19 Pneumonia. Am J Case Rep 17(21):e925849
Hsu CG, Chávez CL, Zhang C, Sowden M, Yan C, Berk BC (2022) The lipid peroxidation product 4-hydroxynonenal inhibits NLRP3 inflammasome activation and macrophage pyroptosis. Cell Death Differ 29(9):1790–1803
Islam H, Chamberlain TC, Mui AL, Little JP (2021) Elevated Interleukin-10 Levels in COVID-19: Potentiation of Pro-Inflammatory Responses or Impaired Anti-Inflammatory Action? Front Immunol 21(12):677008
Jafari-Oori M, Vahedian-Azimi A, Ghorbanzadeh K, Sepahvand E, Dehi M, Ebadi A, Izadi M (2022) Efficacy of ozone adjuvant therapy in COVID-19 patients: a meta-analysis study. Front Med (lausanne) 10(9):1037749
Lu Q, Zhu Z, Tan C, Zhou H, Hu Y, Shen G, Zhu P, Yang G, Xie X (2021) Changes of serum IL-10, IL-1β, IL-6, MCP-1, TNF-α, IP-10 and IL-4 in COVID-19 patients. Int J Clin Pract 75(9):e14462
Mousavizadeh L, Soltani R, Abedini K, Ghasemi S (2022) The relation of the viral structure of SARS-CoV-2, high-risk condition, and plasma levels of IL-4, IL-10, and IL-15 in COVID-19 patients compared to SARS and MERS infections. Curr Mol Med 22(7):584–593
Queiroz MAF, Neves PFMD, Lima SS, Lopes JDC, Torres MKDS, Vallinoto IMVC, Bichara CDA, Dos Santos EF, de Brito MTFM, da Silva ALS, Leite MM, da Costa FP, Viana MNDSA, Rodrigues FBB, de Sarges KML, Cantanhede MHD, da Silva R, Bichara CNC, van den Berg AVS, Veríssimo AOL, Carvalho MDS, Henriques DF, Dos Santos CP, Nunes JAL, Costa IB, Viana GMR, Carneiro FRO, Palacios VRDCM, Quaresma JAS, Brasil-Costa I, Dos Santos EJM, Falcão LFM, Vallinoto ACR (2022) Cytokine profiles associated with acute COVID-19 and long COVID-19 syndrome. Front Cell Infect Microbiol 12:922422
Saha S, Buttari B, Panieri E, Profumo E, Saso L (2020) An overview of Nrf2 signaling pathway and its role in inflammation. Molecules 25(22):5474
Torres M, Casado G, Vigón L, Rodríguez-Mora S, Mateos E, Ramos-Martín F, López-Wolf D, Sanz-Moreno J, Ryan-Murua P, Taboada-Martínez ML, López-Huertas MR, Cervero M, Coiras M (2022) Multidisciplinary Group of Study of COVID-19 (MGS-COVID); Contributing members of the Multidisciplinary Group of Study of COVID-19 (in alphabetical order). Changes in the immune response against SARS-CoV-2 in individuals with severe COVID-19 treated with high dose of vitamin D. Biomed Pharmacother 150:112965
Valdenassi L, Franzini M, Ricevuti G, Rinaldi L, Galoforo AC, Tirelli U (2020) Potential mechanisms by which the oxygen-ozone (O2–O3) therapy could contribute to the treatment against the coronavirus COVID-19. Eur Rev Med Pharmacol Sci 24(8):4059–4061
Wu J, Tan CS, Yu H, Wang Y, Tian Y, Shao W, Zhang Y, Zhang K, Shao H, Ni G, Shen J, Galoforo AC, Wu Q, Ming D (2020) Recovery of four COVID-19 patients via ozonated autohemotherapy. Innovation (camb) 1(3):100060
Zhao Y, Qin L, Zhang P, Li K, Liang L, Sun J, Xu B, Dai Y, Li X, Zhang C, Peng Y, Feng Y, Li A, Hu Z, Xiang H, Ogg G, Ho LP, McMichael A, Jin R, Knight JC, Dong T, Zhang Y (2020) Longitudinal COVID-19 profiling associates IL-1RA and IL-10 with disease severity and RANTES with mild disease. JCI Insight 5(13):e139834
Zheng Z, Dong M, Hu K (2020) A preliminary evaluation on the efficacy of ozone therapy in the treatment of COVID-19. J Med Virol 92(11):2348–2350
Funding
The authors have not disclosed any funding.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors state they have no conflict of interest.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Chirumbolo, S., Pandolfi, S., Franzini, M. et al. Cytokine profiles in COVID-19 patients undergoing adjunct ozone therapy: some comments. Inflammopharmacol 31, 3363–3365 (2023). https://doi.org/10.1007/s10787-023-01359-x
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10787-023-01359-x