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A review on curcumin colon-targeted oral drug delivery systems for the treatment of inflammatory bowel disease

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Abstract

Synthetic drugs and monoclonal antibodies are the typical treatments to combat inflammatory bowel disease (IBD). However, side effects are present when these treatments are used, and their continued application could be restricted by the high relapse rate of the disease. One potential alternative to these treatments is the use of plant-derived products. The use curcumin is one such treatment option that has seen an increase in usage in treating IBD. Curcumin is derived from a rhizome of turmeric (Curcuma longa), and the results of studies on the use of curcumin to treat IBD are promising. These studies suggest that curcumin interacts with cellular targets such as NF-κB, JAKs/STATs, MAPKs, TNF-α, IL-6, PPAR, and TRPV1 and may reduce the progression of IBD. Potentially, curcumin can be used as a therapeutic agent for patients with IBD when it reduces the incidence of clinical relapse. This review discusses the strategies utilized in designing and developing an oral colonic delivery dosage form of curcumin.

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Authors and Affiliations

  1. Targeted Drug Delivery Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

    Hossein Shahdadi Sardou, Mohammadreza Abbaspour & Abbas Akhgari

  2. Department of Pharmaceutics, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

    Hossein Shahdadi Sardou, Mohammadreza Abbaspour & Abbas Akhgari

  3. Food Science and Technology Department, Agriculture Faculty, Ferdowsi University of Mashhad (FUM), Mashhad, Iran

    Paria Rahnama Vosough

  4. Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Hull, UK

    Thozhukat Sathyapalan

  5. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

    Amirhossein Sahebkar

  6. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

    Amirhossein Sahebkar

  7. Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Amirhossein Sahebkar

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  1. Hossein Shahdadi Sardou
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  2. Paria Rahnama Vosough
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  3. Mohammadreza Abbaspour
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  4. Abbas Akhgari
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  5. Thozhukat Sathyapalan
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  6. Amirhossein Sahebkar
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Correspondence to Amirhossein Sahebkar.

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Sardou, H.S., Vosough, P.R., Abbaspour, M. et al. A review on curcumin colon-targeted oral drug delivery systems for the treatment of inflammatory bowel disease. Inflammopharmacol 31, 1095–1105 (2023). https://doi.org/10.1007/s10787-023-01140-0

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  • DOI: https://doi.org/10.1007/s10787-023-01140-0

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