Abstract
Our main aim is in the present investigation, development and evaluation of seabuckthorn oil-based Emulgel formulation for psoriasis therapy. Anti-psoriatic activity of the SeaEmulgel was studied using Imiquimod-induced psoriasis-like inflammation model Balb/c mice and parameters such as PASI score, ear thickness, spleen to body weight index including histological staining studies, enzyme-linked immune sorbent assay (ELISA), skin compliance and safety evaluation of sea buckthorn oil was performed. The globule size and PDI of sea buckthorn oil emulsion were found to be 172.70 ± 1.73 nm and 0.117 ± 0.018, respectively. In-vivo animal studies performed on male Balb/c mice and emulgel showed a reduction in redness, scaling, inflammation in psoriasis-induced mice, which was analysed by PASI scoring, body weight, spleen weight index and ear thickness. The current investigation clearly revealed the better anti-psoriatic activity of SeaEmulgel formulation against imiquimod-induced psoriasis-like skin inflammation Balb/c mice model.
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References
Arora R, Katiyar SS, Kushwah V, Jain S (2017) Solid lipid nanoparticles and nanostructured lipid carrier-based nanotherapeutics in treatment of psoriasis: a comparative study. Expert Opin Drug Deliv 14(2):165–177. https://doi.org/10.1080/17425247.2017.1264386
Bhagavathi Kandy S, Simon GP, Cheng W, Zank J, Joshi K, Gala D, Bhattacharyya AR (2018) Effect of incorporation of multiwalled carbon nanotubes on the microstructure and flow behavior of highly concentrated emulsions. ACS Omega 3(10):13584–13597. https://doi.org/10.1021/acsomega.8b00579
Buggins TR, Dickinson PA, Taylor G (2007) The effects of pharmaceutical excipients on drug disposition. Adv Drug Deliv Rev 59(15):1482–1503. https://doi.org/10.1016/j.addr.2007.08.017
Burki IK, Khan MK, Khan BA, Uzair B, Braga VA, Jamil QA (2020) Formulation development, characterization, and evaluation of a novel dexibuprofen-capsaicin skin emulgel with improved in vivo anti-inflammatory and analgesic effects. AAPS PharmSciTech 21(6):1–14. https://doi.org/10.1208/s12249-020-01760-7
Chang M, Guo Y, Jiang Z, Shi L, Zhang T, Wang Y, Gong M, Wang T, Lin R, Liu R, Wang Y, Jin Q, Wang X (2020) Sea buckthorn pulp oil nanoemulsions fabricated by ultra-high pressure homogenization process: a promising carrier for nutraceutical. J Food Eng 287:110129. https://doi.org/10.1016/J.JFOODENG.2020.110129
De S, Malik S, Ghosh A, Saha R, Saha B (2015) A review on natural surfactants. RSC Adv 5(81):65757–65767. https://doi.org/10.1039/c5ra11101c
Effendy I, Maibach HI (1995) Surfactants and experimental irritant contact dermatitis. Contact Dermat 33(4):217–225. https://doi.org/10.1111/j.1600-0536.1995.tb00470.x
Griffiths CEM, Armstrong AW, Gudjonsson JE, Barker JNWN (2021) Psoriasis. Lancet 397(10281):1301–1315. https://doi.org/10.1016/S0140-6736(20)32549-6
Kim W, Wang Y, Selomulya C (2020) Dairy and plant proteins as natural food emulsifiers. Trends Food Sci Technol 105:261–272. https://doi.org/10.1016/j.tifs.2020.09.012
Ma X, Chatterton DEW (2021) Strategies to improve the physical stability of sodium caseinate stabilized emulsions: a literature review. Food Hydrocoll. https://doi.org/10.1016/j.foodhyd.2021.106853
Mehra NK, Tekmal RR, Palakurthi S (2018) Development and evaluation of talazoparib nanoemulsion for systemic therapy of BRCA1-mutant cancer. Anticancer Res 38(8):4493–4503. https://doi.org/10.21873/ANTICANRES.12753
Meng S, Sun L, Wang L, Lin Z, Liu Z, Xi L, Wang Z, Zheng Y (2019) Loading of water-insoluble celastrol into niosome hydrogels for improved topical permeation and anti-psoriasis activity. Coll Surf b: Biointerfaces 182:110352. https://doi.org/10.1016/j.colsurfb.2019.110352
Miguel MG (2010) Antioxidant and anti-inflammatory activities of essential oils: a short review. Molecules 15(12):9252–9287. https://doi.org/10.3390/molecules15129252
Mwangi AN, Njogu PM, Maru SM, Njuguna NM, Njaria PM, Kiriiri GK, Mathenge AW (2021) Meloxicam emulgels for topical management of rheumatism: formulation development, in vitro and in vivo characterization. Saudi Pharm J 29(4):351–360. https://doi.org/10.1016/j.jsps.2021.03.005
Nakamizo Y (1977) Topical treatment of psoriasis. Nishinihon J Dermatol 39(6):855–859. https://doi.org/10.2336/nishinihonhifu.39.855
Nickoloff BJ, Xin H, Nestle FO, Qin JZ (2007) The cytokine and chemokine network in psoriasis. Clin Dermatol 25(6):568–573. https://doi.org/10.1016/j.clindermatol.2007.08.011
Raharja A, Mahil SK, Barker JN (2021) Psoriasis: a brief overview. Clinical medicine. J R Coll Physicians Lond 21(3):170–173. https://doi.org/10.7861/CLINMED.2021-0257
Rahman M, Alam K, Ahmad MZ, Gupta G, Afzal M, Akhter S, Kazmi I, Ahmad FJ, Jyoti, Anwar F (2012a) Classical to current approach for treatment of psoriasis: a review. Endocr, Metab Immune Disord - Drug Targets 12(3):287–302. https://doi.org/10.2174/187153012802002901
Rahman M, Zaki Ahmad M, Kazmi I, Akhter S, Beg S, Gupta G, Afzal M, Saleem S, Ahmad I, Adil Shaharyar Md, Jalees Ahmed F, Anwar F (2012b) Insight into the biomarkers as the novel anti-psoriatic drug discovery tool: a contemporary viewpoint. Curr Drug Discov Technol 9(1):48–62. https://doi.org/10.2174/157016312799304516
Sabalingam S, Siriwardhene MA (2022) A review on emerging applications of emulgel as topical drug delivery system. World J Adv Res Rev 13(1):452–463. https://doi.org/10.3074/wjarr.2022.13.1.0048
Singh BK, Tiwari S, Dubey NK (2021) Essential oils and their nanoformulations as green preservatives to boost food safety against mycotoxin contamination of food commodities: a review. J Sci Food Agric 101(12):4879–4890. https://doi.org/10.1002/jsfa.11255
Tadros T, Izquierdo P, Esquena J, Solans C (2004) Formation and stability of nano-emulsions. Adv Coll Interface Sci 108–109:303–318. https://doi.org/10.1016/j.cis.2003.10.023
Thatikonda S, Pooladanda V, Godugu C (2020) Repurposing an old drug for new use: niclosamide in psoriasis-like skin inflammation. J Cell Physiol 235(6):5270–5283. https://doi.org/10.1002/jcp.29413
World Health Organization psoriasis (2016) Global report on. Global Rep Psoriasis 978:1–26
Zheng H, Mao L, Yang J, Zhang C, Miao S, Gao Y (2020) Effect of oil content and emulsifier type on the properties and antioxidant activity of sea buckthorn oil-in-water emulsions. J Food Qual. https://doi.org/10.1155/2020/1540925
Zhu XF, Zheng J, Liu F, Qiu CY, Lin WF, Tang CH (2018) Freeze-thaw stability of Pickering emulsions stabilized by soy protein nanoparticles. Influence of ionic strength before or after emulsification. Food Hydrocoll 74:37–45. https://doi.org/10.1016/j.foodhyd.2017.07.017
Zielińska A, Nowak I (2017) Abundance of active ingredients in sea-buckthorn oil. Lipids Health Dis 16(1):1–11. https://doi.org/10.1186/s12944-017-0469-7
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Authors would like to acknowledge the Department of Pharmaceutics, National Institute of Pharmaceutical Education & Research (NIPER), Hyderabad (Ministry of Chemical and Fertilizers, India) for providing extending facilities during this manuscript (Manuscript communication no.: NIPER-H/2022-xxx).
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Sulthana, S., Chary, P.S., Bhavana, V. et al. Development and evaluation emulgel for effective management of the imiquimod-induced psoriasis. Inflammopharmacol 31, 301–320 (2023). https://doi.org/10.1007/s10787-022-01131-7
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DOI: https://doi.org/10.1007/s10787-022-01131-7