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Phytochemicals as potential target on thioredoxin-interacting protein (TXNIP) for the treatment of cardiovascular diseases

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Abstract

Cardiovascular diseases (CVDs) are currently the major cause of death and morbidity on a global scale. Thioredoxin-interacting protein (TXNIP) is a marker related to metabolism, oxidation, and inflammation induced in CVDs. The overexpression of TXNIP is closely related to the occurrence and development of CVDs. Hence, TXNIP inhibition is critical for reducing the overactivation of its downstream signaling pathway and, as a result, myocardial cell damage. Due to the chemical variety of dietary phytochemicals, they have garnered increased interest for CVDs prevention and therapy. Phytochemicals are a source of medicinal compounds for a variety of conditions, which aids in the development of effective and safe TXNIP-targeting medications. The objective of this article is to find and virtual screen novel safe, effective, and economically viable TXNIP inhibitors from flavonoids, phenols, and alkaloids derived from foods and plants. The results of the docking study revealed that silibinin, rutin, luteolin, baicalin, procyanidin B2, hesperetin, icariin, and tilianin in flavonoids, polydatin, resveratrol, and salidroside in phenols, and neferine in alkaloids had the highest Vina scores, indicating that these compounds are the active chemicals on TXNIP. In particular, silibinin can be utilized as a lead chemical in the process of structural alteration. These dietary phytochemicals may aid in the discovery of lead compounds for the development of innovative TXNIP agents for the treatment of cardiovascular disease.

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Data availability

The data used to support the findings of this study are available from the corresponding author upon request.

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Funding

This work was financially supported by the Key Project Foundation of Natural Science Research in Universities of Anhui Province in China (2022AH050479 and KJ2021A1167), Outstanding Youth Scientific Research Project of Anhui Universities (2022AH030158), and Open Fund of State Key Laboratory of Tea Plant Biology and Utilization (SKLTOF20210112).

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  1. Peng Zhou and Yao-yao Ma contributed equally to this work.

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  1. Department of Integrated Traditional Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, Anhui, People’s Republic of China

    Peng Zhou, Yao-yao Ma & Xiao-ni Zhao

  2. School of Pharmacy, Anhui Xinhua University, Hefei, Anhui, People’s Republic of China

    Fang Hua

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  1. Peng Zhou
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Zhou, P., Ma, Yy., Zhao, Xn. et al. Phytochemicals as potential target on thioredoxin-interacting protein (TXNIP) for the treatment of cardiovascular diseases. Inflammopharmacol 31, 207–220 (2023). https://doi.org/10.1007/s10787-022-01130-8

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