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Effects of Quinoa (Chenopodium quinoa) on inflammatory mediators: a systematic review of preclinical studies

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Abstract

The aim of the current systematic review was to gather the researches about the effect of quinoa (chenopodium quinoa) on inflammatory parameters interleukin-6 (IL-6), interleukin-1β (IL-1β), and tumor necrosis factor-alpha (TNF-α). Search was performed using PubMed, Scopus, WOS, ProQuest, and Google scholar databases without any restriction on language or publication date until July 2022 and search alert services were used to detect novel papers published after the initial search. Only 20 animal and in vitro investigations were eligible for this systematic review. According to in vitro researches and 8 of 14 animal investigations, IL-6, IL-1β, and TNF-α level decreased remarkably after quinoa administration, which indicates the capability of quinoa in alleviating inflammatory factors. Quinoa is favorable but not yet a confirmed agent for alleviating systemic inflammation in inflammatory diseases.

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This manuscript has no associated data or the data will not be deposited. [Authors' comment: Data is available upon request from the Authors].

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Funding

This study was financially supported by the Research Vice-Chancellor of Tabriz University of Medical Sciences, Tabriz, Iran (Grant Number: 70940).

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Authors and Affiliations

  1. Connective Tissue Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Aida Malek Mahdavi

  2. Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Aida Malek Mahdavi

  3. Rahat Breathe and Sleep Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Aida Malek Mahdavi & Majid Khalili

  4. Department of Health Education & Promotion, Faculty of Health, Tabriz University of Medical Sciences, Tabriz, Iran

    Zeinab Javadivala

  5. Faculty of Dentistry, Necmettin Erbakan University, Konya, Turkey

    Yeganeh Khalili

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  1. Aida Malek Mahdavi
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  2. Zeinab Javadivala
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  3. Yeganeh Khalili
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  4. Majid Khalili
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Correspondence to Aida Malek Mahdavi.

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Malek Mahdavi, A., Javadivala, Z., Khalili, Y. et al. Effects of Quinoa (Chenopodium quinoa) on inflammatory mediators: a systematic review of preclinical studies. Inflammopharmacol 31, 241–251 (2023). https://doi.org/10.1007/s10787-022-01091-y

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  • DOI: https://doi.org/10.1007/s10787-022-01091-y

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