Abstract
Gastroprotective is an effect caused by the compounds that have the capability of protecting the gastric mucosa. Peperomia pellucida L. plants contain alkaloids, flavonoids, saponins, tannins, and terpenoids, while Pachyrhizus erosus L. contains flavonoids, alkaloids, tannins, and saponins. Peperomia pellucida L. reportedly contains dillapiole compounds with a gastroprotective effect. Moreover, its isolation result from Pachyrhizus erosus L. indicates the presence of dulcitol, gentisic acid, and formononetin, which has antioxidant activity. This study aims to determine the gastroprotective effect of the combination of Peperomia pellucida L. and Pachyrhizus erosus L. extract on rats with gastric ulcer models by looking at the ulcer index, percentage of inhibition, and histopathology. The research method used in this study was by making a combination of Peperomia pellucida L. and Pachyrhizus erosus L. extract. The combined extract was then given to five treatment groups. Group I as a negative control, group II as a positive control was given sucralfate, groups III, IV, and V were given a combination of Peperomia pellucida L. and Pachyrhizus erosus L. extract of 100, 200, and 400 mg/kg BW. The treatment was given orally for 14 days, after 1 h of treatment on the 14th day, 96% ethanol induction was given orally at a dose of 5 mg/kg BW. The animal dissection was performed 24 h after the induction. The results from observations showed an increase in body weight before and after the treatment. The ulcer index produced by negative control, positive control in the treatment with doses of 100, 200, and 400 were 4.18; 2.98; 2.42; 2.04; and 1.07. This study showed that the combination of Peperomia pellucida L. and Pachyrhizus erosus L. extract has a gastroprotective effect.
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To avoid plagiarism, the datasets generated during and/or analysed during the current study are not publicly available but are available from the corresponding author on reasonable request.
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Acknowledgements
The authors would like to thank those who have helped a lot in this research. The deepest gratitude is addressed to Institute for Research and Community Service, University of Bengkulu, for the opportunity given so we could carry out this university development research with contract number 1811/UN30.15/PG/2021.
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This work was supported by the University of Bengkulu (UNIB) on the theme contract number 1811/UN30.15/PG/2021.
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RP: contributed to the main study’s conception and design. Material preparation was permormed by SPYS and AGS. RP, AH, NKW, TP, DN, and RHW: collected and analyzed data. The first draft of the manuscript was written by RP, and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.
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This study was performed in line with the principles of the International Association for the Study of Pain (IASP) Guidelines for the Use of Animals in Research. Approval was granted by the Ethics Committee of the University of Bengkulu (18 Oct 2021/No: 240/UN30.14.9/LT/2021).
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Pertiwi, R., Samudra, A.G., Wati, N.K. et al. Gastroprotective activities of Peperomia pellucida L. and Pachyrhizus erosus L. extracts combination on ethanol-induced rats. Inflammopharmacol 30, 2139–2144 (2022). https://doi.org/10.1007/s10787-022-00982-4
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DOI: https://doi.org/10.1007/s10787-022-00982-4