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Evaluation of the effects of extracts of Maytenus imbricata (Celastraceae) on the treatment of inflammatory and metabolic dysfunction induced by high-refined carbohydrate diet

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Abstract

The Maytenus genus is a member of the Celastraceae family. Numerous medicinal uses were assigned to species of this genus, with the use of roots, bark, and leaves for the treatment of gastric ulcers, as anti-inflammatory, analgesic, antiallergic, antitumor, among others. Several studies have demonstrated that natural products derived from plants have an important role in the prevention and treatment of obesity. Accordingly, we evaluated the effect of Maytenus imbricata extracts in the treatment of obesity induced by diet rich in refined carbohydrate (HC). BALB/c mice were fed chow or HC diet for 8 weeks. At the beginning of the 9th week, the HC group was subdivided into three groups: (i) group of animals that continued to consume only HC diet; (ii) the group of animals fed HC diet supplemented with ethyl acetate extract of M. imbricata roots (HC + EAE); (iii) the group of animals fed HC diet supplemented with extract in hexane/ethyl ether (HC + HEE). The period of extracts supplementation was 4 weeks. It was observed that EAE and EHE when added to the HC diet modulated the metabolic and inflammatory changes, such as: reduced the adipocytes area, improved glucose intolerance, reduced the levels of triglycerides and resistin in serum, and the number of total leukocytes in blood. In the epididymal adipose tissue, the extracts reduced proinflammatory mediators’ concentration. According to the results, it was concluded that the species Maytenus imbricata has the potential to be used for the treatment of obesity.

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Acknowledgements

This work was supported by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES-Brazil) and Conselho Nacional de Pesquisa (CNPq-Brazil).

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Authors and Affiliations

  1. Pharmaceutical Sciences Faculty, Federal University of Amazonas (UFAM), Manaus, Amazonas, Brazil

    C. C. Veloso

  2. Department of Nutrition, Nursing School, Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil

    M. C. Oliveira & A. V. M. Ferreira

  3. Imunopharmacology, Department of Biochemistry and Immunology, Institute of Biological Sciences, UFMG, Belo Horizonte, Minas Gerais, Brazil

    M. C. Oliveira, M. M. Teixeira & A. V. M. Ferreira

  4. Department of Chemistry, Institute of Exact Sciences, UFMG, Belo Horizonte, Minas Gerais, Brazil

    V. G. Rodrigues & L. P. Duarte

  5. Department of Pharmacology, Institute of Biological Sciences, UFMG, Belo Horizonte, Minas Gerais, Brazil

    C. C. Oliveira & A. C. Perez

  6. Faculdade de Ciências Farmacêuticas, Universidade Federal do Amazonas (UFAM), Av. General Rodrigo Octávio Jordão Ramos, 3000, Coroado I, Manaus, Amazonas, 69.077-000, Brazil

    C. C. Veloso

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  1. C. C. Veloso
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Veloso, C.C., Oliveira, M.C., Rodrigues, V.G. et al. Evaluation of the effects of extracts of Maytenus imbricata (Celastraceae) on the treatment of inflammatory and metabolic dysfunction induced by high-refined carbohydrate diet. Inflammopharmacol 27, 539–548 (2019). https://doi.org/10.1007/s10787-018-0496-7

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  • DOI: https://doi.org/10.1007/s10787-018-0496-7

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