Approximately, one-third of those who develop major depression will have a poor response to treatment and over time can become treatment resistant. Intestinal dysbiosis has been implicated in depression with systemic inflammation and vagal and enteric nerve impairment. We report on a sequel pilot study (n = 12) with a combination probiotics/magnesium orotate formulation adjuvant administered with SSRIs for treatment resistant depression. At the end of an 8-week intervention mean changes for depression scores and quality of life in the group was clinically significantly improved (p < 0.001) with all but 4 participants experiencing a benefit. An intestinal anti-inflammatory response was suggested. At 16-weeks follow-up while still on SSRI medications, the group had relapsed after cessation of the test intervention.
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Luis Vitetta has received National Institute of Complementary Medicine and National Health and Medical Research Council of Australia competitive funding and Industry support for research into nutraceuticals and probiotics. In addition, Luis Vitetta and Sean Hall are involved in research with probiotics at Medlab Clinical. Medlab Clinical provided seed funding and the investigational product (NRGBiotic) (containing specific probiotic species and Magnesium Orotate and specific laboratory testing of the product).
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Bambling, M., Edwards, S.C., Hall, S. et al. A combination of probiotics and magnesium orotate attenuate depression in a small SSRI resistant cohort: an intestinal anti-inflammatory response is suggested. Inflammopharmacol 25, 271–274 (2017). https://doi.org/10.1007/s10787-017-0311-x