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LPS and neuroinflammation: a matter of timing

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Abstract

Lipopolysaccharide (LPS) administration has been repeatedly shown to elicit central inflammation, regardless of the route of administration. In a recent study, Tiwari et al. (Inflammopharmacology 10.1007/s10787-016-0274-3, 2016) dispute the potential of peripheral administration of LPS to induce neuroinflammation. Here, I summarise literature indicating that the neuroinflammatory effects of LPS are time dependent, and suggest that their findings can be explained by the time at which they chose to measure neuroinflammation.

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Authors and Affiliations

  1. Department of Evolutionary Biology and Environmental Studies, University of Zurich, Zurich, Switzerland

    Patricia C. Lopes

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  1. Patricia C. Lopes
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Correspondence to Patricia C. Lopes.

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Lopes, P.C. LPS and neuroinflammation: a matter of timing. Inflammopharmacol 24, 291–293 (2016). https://doi.org/10.1007/s10787-016-0283-2

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  • DOI: https://doi.org/10.1007/s10787-016-0283-2

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