, Volume 23, Issue 6, pp 337–341 | Cite as

A comparison of the leaf gel extracts of Aloe ferox and Aloe vera in the topical treatment of atopic dermatitis in Balb/c mice

  • M. J. Finberg
  • G. L. Muntingh
  • C. E. J. van RensburgEmail author
Short Communication


Aloe vera gel is widely used in the treatment of an array of disturbances, especially skin disorders. The wound-healing effects have been attributed to its moisturizing and anti-inflammatory effects as well as its beneficial effect on the maturation of collagen. The aim of the present study is to compare the effects of topically applied extracts of Aloe ferox with that of Aloe vera on the symptoms as well as IgE levels of a mouse model of atopic dermatitis (AD). Mice were sensitized and challenged with 2,4-dinitrochlorobenzene and treated afterwards for 10 consecutive days with the gels of either A. ferox or A. vera applied topically to the affected areas. A placebo gel was used for the control mice. Blood was collected at the beginning and end of the treatment period to measure serum IgE levels. Although the gels of both the Aloe species inhibited the cutaneous inflammatory response as well as serum IgE levels in the rats, the extracts of A. ferox were superior to that of A. vera in reducing IgE levels. The gels of A. ferox and A. vera, applied topically, may be a safe and useful alternative to antihistamines and topical corticosteroids, for the treatment of patients suffering from recurring chronic AD.


Atopic dermatitis Topical treatment Aloe ferox Aloe vera 



This study was supported by a Grant from the House of Aloes, Albertinia, South Africa.


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Copyright information

© Springer Basel 2015

Authors and Affiliations

  • M. J. Finberg
    • 1
  • G. L. Muntingh
    • 1
  • C. E. J. van Rensburg
    • 2
    Email author
  1. 1.Department of Pharmacology, School of Medicine, Faculty of Health ScienceUniversity of PretoriaPretoriaSouth Africa
  2. 2.Office of the Dean, Faculty of Health ScienceUniversity of PretoriaPretoriaSouth Africa

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