, Volume 23, Issue 1, pp 65–70 | Cite as

Dual inhibition of arachidonic acid pathway by mulberry leaf extract

  • Seema Chauhan
  • Uma Devi
  • Venkatesh R. Kumar
  • Vikas Kumar
  • Firoz Anwar
  • Gaurav KaithwasEmail author
Research Article


The present work investigates the anti-inflammatory, analgesic and antipyretic activity of methanolic extract of mulberry leaves of variety S-1, S-13 and S-146. The S-146 extract was further evaluated for its efficacy against adjuvant arthritis in albino rats followed by inhibitory potential for COX 1, COX 2 and 5 LOX. The HPLC analysis enumerated the presence of morin, reversterol, scopoletin and 7-hydroxy coumarin as the major constituents. The anti-inflammatory, antipyretic and analgesic activity observed in the present experiment could be accredited to the dual inhibition in the AA pathway. The inhibition of COX and LOX enzymes could be imparted to the presence of resveraterol, morin, scopoletin and 7-hydroxy coumarin.


Adjuvant arthritis Cyclooxygenase Inflammation Lipoxygenase Morus alba 


Conflict of interest

Authors declare that we do not have conflicts of interest.


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Copyright information

© Springer Basel 2014

Authors and Affiliations

  • Seema Chauhan
    • 1
  • Uma Devi
    • 2
  • Venkatesh R. Kumar
    • 1
  • Vikas Kumar
    • 3
  • Firoz Anwar
    • 4
  • Gaurav Kaithwas
    • 2
    Email author
  1. 1.Department of Applied Plant SciencesSB&BT, Babasaheb Bhimrao Ambedkar UniversityLucknowIndia
  2. 2.Department of Pharmaceutical SciencesSB&BT, Babasaheb Bhimrao Ambedkar UniversityLucknowIndia
  3. 3.Department of Pharmaceutical SciencesFHMSIASM, SHIATS-Deemed University (Formerly Allahabad Agriculture Institute)AllahabadIndia
  4. 4.Sidharatha Institute of PharmacyDehradunIndia

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