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Influence of inhaled beclomethasone and montelukast on airway remodeling in mice

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Abstract

This study examined the effect of montelukast and beclomethasone on airway remodeling in murine model of asthma. Mice were sensitized by i.p. injection of ovalbumin (OVA) on days 0 and 14, and then challenged by nebulization of 1% OVA 3 days/week for 6 or 10 weeks. Results of 6-week OVA-challenged group showed moderate inflammation, but the 10-week OVA-challenged group exhibited mild inflammation. The OVA challenge (6 and 10 weeks) exhibited marked airway fibrosis, illustrated by significant increase in goblet cell hyperplasia and epithelial thickness, increased lung content of collagen and transforming growth factor-β1, together with a decrease in nitric oxide production; also, there was an increase in bronchoalveolar lavage fluid level of interleukin-13. Administration of montelukast or beclomethasone before each OVA challenge was capable of restoring most of the measured parameters to near normal levels. Inhalation of beclomethasone has a similar role in airway remodeling as montelukast, but its effects in regulating inflammatory changes is less pronounced than montelukast.

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Authors and Affiliations

  1. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt

    Rania R. Abdel Aziz, Nadia Y. Helaly & Nariman M. Gameil

  2. Clinical Pathology Unit, Faculty of Medicine, Mansoura University, Mansoura, Egypt

    Khaled R. Zalata

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  1. Rania R. Abdel Aziz
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  2. Nadia Y. Helaly
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  3. Khaled R. Zalata
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Correspondence to Rania R. Abdel Aziz.

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Abdel Aziz, R.R., Helaly, N.Y., Zalata, K.R. et al. Influence of inhaled beclomethasone and montelukast on airway remodeling in mice. Inflammopharmacol 21, 55–66 (2013). https://doi.org/10.1007/s10787-012-0127-7

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