Modulation of lipopolysaccharide-induced pro-inflammatory mediators by an extract of Glycyrrhiza glabra and its phytoconstituents

Inflammopharmacology volume 19, pages235–241(2011)Cite this article

Abstract

Objective

To evaluate the inhibitory property of de-glycyrrhizinated extract of Glycyrrhiza glabra root and its phytoconstituents (glabridin, isoliquiritigenin and glycyrrhizin) on LPS-induced production of pro-inflammatory mediators.

Materials and methods

Inhibitory effect of G. glabra extract and its phytoconstituents were studied on lipopolysaccharide (LPS)-induced nitric oxide (NO), interleukin-1 beta (IL-1 beta) and interleukin-6 (IL-6) levels in J774A.1 murine macrophages.

Results

G. glabra and isoliquiritigenin significantly inhibited LPS stimulated NO, IL-1 beta and IL-6 production. Glabridin showed significant inhibition of NO and IL-1 beta release, but failed to attenuate IL-6 levels at the tested concentrations. In addition, glycyrrhizin did not exhibit inhibitory response towards any of the LPS-induced pro-inflammatory mediators at the tested concentrations.

Conclusion

From the results we speculate that the inhibitory effect of G. glabra extract on LPS-induced pro-inflammatory mediators is influenced by glabridin and isoliquiritigenin and is not contributed by glycyrrhizin.

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Affiliations

  1. Department of Cellular Assay, R&D Centre, Natural Remedies Pvt. Ltd, Plot No. 5B, Veerasandra Indl. Area, 19th K. M. Stone, Hosur Road, Bangalore, 560100, India

    P. Thiyagarajan, C. V. Chandrasekaran, H. B. Deepak & Amit Agarwal

Authors
  1. P. Thiyagarajan
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  2. C. V. Chandrasekaran
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  3. H. B. Deepak
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  4. Amit Agarwal
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Correspondence to C. V. Chandrasekaran.

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Thiyagarajan, P., Chandrasekaran, C.V., Deepak, H.B. et al. Modulation of lipopolysaccharide-induced pro-inflammatory mediators by an extract of Glycyrrhiza glabra and its phytoconstituents. Inflammopharmacol 19, 235–241 (2011). https://doi.org/10.1007/s10787-011-0080-x

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Keywords

  • Glycyrrhiza glabra
  • Phytoconstituents (glabridin, isoliquiritigenin and glycyrrhizin)
  • Inflammation
  • Pro-inflammatory mediators (NO, IL-1 beta and IL-6)