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Inflammopharmacology

, Volume 18, Issue 3, pp 137–145 | Cite as

Evaluation of antiulcer and antisecretory potential of Linum usitatissimum fixed oil and possible mechanism of action

  • Gaurav Kaithwas
  • Dipak K. MajumdarEmail author
Research Article

Abstract

The aim of the study was to evaluate the antiulcer activity of Linum usitatissimum fixed oil against aspirin-, indomethacin-, ethanol-, reserpine-, serotonin- and stress-induced gastric ulceration in rats and histamine-induced gastric ulceration in guinea pigs. Attempts were also made to evaluate the in vitro anticholinergic and antihistaminic activity and in vivo antisecretary and antiulcer activity of oil following pylorus ligation in rats. L. usitatissimum fixed oil exhibited significant antiulcer activity against different ulcerogens in experimental animal models. The fixed oil significantly inhibited acetylcholine- and histamine-induced contraction of guinea pig and rat ileums, respectively, suggesting its anticholinergic and antihistaminic activity. The oil also exhibited significant inhibitory effect on gastric secretion/total acidity and aspirin-induced gastric ulceration in pylorus-ligated rats. The lipoxygenase inhibitory, histamine antagonistic and antisecretory (anticholinergic) effects of the oil could probably have contributed towards antiulcer activity. L. usitatissimum fixed oil may be considered to be a drug of natural origin which possesses significant antiulcer activity. The present observation is the first experimental data showing antiulcer activity of L. usitatissimum fixed oil.

Keywords

Lipoxygenase-inhibitor Antihistaminic Anticholinergic Antisecretory Flaxseed oil Linseed oil 

Notes

Acknowledgments

The authors would like to thank Arbro Pharmaceuticals Limited (New Delhi, India) for supplying drug samples, mentioned in the text, as generous gift. Thanks are also due, to Ranbaxy Research Laboratories (Gurgaon, India) for analysis of Linseed oil.

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Copyright information

© Springer Basel AG 2010

Authors and Affiliations

  1. 1.Department of Pharmaceutical Sciences, Faculty of Health and Medical SciencesAllahabad Agricultural Institute-Deemed UniversityAllahabadIndia
  2. 2.PharmaceuticsDelhi Institute of Pharmaceutical Sciences and Research (Formerly College of Pharmacy), University of DelhiNew DelhiIndia

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