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Antioxidant, anti-inflammatory and analgesic potential of the Citrus decumana L. peel extract

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Abstract

The present study was designed to investigate the antioxidant, anti-inflammatory and analgesic potential of Citrus decumana peel extract. Antioxidant activity of Citrus decumana peel extract in four solvent systems was evaluated by 1,1-diphenyl-2-picrylhydrazyl (DPPH·) and hydrogen peroxide (H2O2) radical scavenging methods. Ethyl acetate peel extract of Citrus decumana (EtCD) was studied for its anti-inflammatory and analgesic activities at a dose level of 100, 200 and 300 mg/kg. Anti-inflammatory activity was performed using carrageenan-induced paw edema in rats. Analgesic activity was evaluated for its central and peripheral pharmacological actions in mice. EtCD showed significant antioxidant activity in a dose-dependent manner when compared with ascorbic acid. EtCD at the dose of 300 mg/kg produced significant decrease in paw volume and pain when compared with reference drug diclofenac and morphine, respectively. The Citrus decumana peel extract may be useful as a natural antioxidant in the treatment of inflammation and pain.

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Acknowledgments

Thanks to Professor P. K. Karar and all faculty members of Rayat Institute of Pharmacy for their encouragement and support. We are also grateful to Rayat and Bahra Educational and Research Trust for their unconditional help to carryout this project.

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Authors and Affiliations

  1. Rayat Institute of Pharmacy, Nawanshahr District, Near Railmajra, Ropar, 144533, Punjab, India

    Shailja Sood, Bhawna Arora, Stuti Bansal, Arunachalam Muthuraman, Naresh Singh Gill & Rashmi Arora

  2. Rayat Institute of Engineering and Technology, Ropar Campus, Railmajra, Ropar, 144533, Punjab, India

    Manoj Bali

  3. University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India

    Pritam Dev Sharma

Authors
  1. Shailja Sood
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  2. Bhawna Arora
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  3. Stuti Bansal
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  4. Arunachalam Muthuraman
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  5. Naresh Singh Gill
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  6. Rashmi Arora
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  7. Manoj Bali
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  8. Pritam Dev Sharma
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Correspondence to Shailja Sood.

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Sood, S., Arora, B., Bansal, S. et al. Antioxidant, anti-inflammatory and analgesic potential of the Citrus decumana L. peel extract. Inflammopharmacol 17, 267–274 (2009). https://doi.org/10.1007/s10787-009-0015-y

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  • DOI: https://doi.org/10.1007/s10787-009-0015-y

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