Anti-inflammatory activities of ethanolic extract of Carica papaya leaves


The anti-inflammatory activity of an ethanolic extract of Carica papaya leaves was investigated in rats using carrageenan induced paw oedema, cotton pellet granuloma and formaldehyde induced arthritis models. Experimental animals received 25–200 mg/Kg (orally) of the extracts or saline (control group) and the reference group received 5 mg/ Kg of indomethacin. The ulcerogenic activity of the extract was also investigated. The results show that the extracts significantly (p <0.05) reduced paw oedema in the carrageenan test. Likewise the extract produced significant reduction in the amount of granuloma formed from 0.58 ±0.07 to 0.22 ±0.03 g. In the formaldehyde arthritis model, the extracts significantly reduced the persistent oedema from the 4th day to the 10th day of the investigation. The extracts also produced slight mucosal irritation at high doses. The study establishes the anti-inflammatory activity of Carica papaya leaves.

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Correspondence to Bamidele V. Owoyele.

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Received 12 October 2007; accepted 3 April 2008

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Owoyele, B.V., Adebukola, O.M., Funmilayo, A.A. et al. Anti-inflammatory activities of ethanolic extract of Carica papaya leaves. Inflammopharmacol 16, 168–173 (2008).

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  • Anti-inflammatory
  • Arthritis
  • Carica papaya
  • Extracts
  • Gastric mucosa
  • Oedema
  • Rats
  • Ulcer