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Anti-inflammatory effect of α, β-Amyrin, a pentacyclic triterpene from Protium heptaphyllum in rat model of acute periodontitis

Abstract.

This study was aimed to evaluate the anti-inflammatory potential of triterpene α, β-amyrin in rats on acute phase periodontitis. Periodontitis was induced by ligature placement around the maxillary right second molar tooth. Rats (n = 8/group) were pretreated with α, β-amyrin (5 and 10 mg/kg, p. o.), two hours before the induction of periodontal inflammation. Sham-operated and positive controls (lumiracoxib and dexamethasone) were included. Six hours later, plasma levels of TNF-alpha were analysed. Rats were sacrificed at 24 h, and the gingival tissue analysed for myeloperoxidase (MPO) and thiobarbituric acid-reactive substances (TBARS), as measures of neutrophil influx and lipid-peroxidation, respectively α, β-Amyrin as well as dexamethasone significantly inhibited the periodontitis-associated increases of TNF-alpha, and the gingival MPO and TBARS. α, β-Amyrin effect was more prominent at 5 mg/kg. Lumiracoxib manifested varied influence on the studied parameters. These results provide evidence to show that α, β-Amyrin retards acute inflammation in rat model of periodontitis and warrant further study on its efficacy to prevent chronic periodontitis-associated bone loss.

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Correspondence to V. S. Rao.

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Received 21 March 2007; revised 22 June 2007; accepted 6 July 2007

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Holanda Pinto, S.A., Pinto, L.M.S., Cunha, G.M.A. et al. Anti-inflammatory effect of α, β-Amyrin, a pentacyclic triterpene from Protium heptaphyllum in rat model of acute periodontitis. Inflammopharmacol 16, 48–52 (2008). https://doi.org/10.1007/s10787-007-1609-x

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  • DOI: https://doi.org/10.1007/s10787-007-1609-x

Keywords:

  • α, β-Amyrin
  • triterpene
  • acute phase periodontitis
  • TNF-alpha
  • MPO and TBARS
  • anti-inflammatory activity