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Interaction of VEGF to gastric low grade MALT lymphoma by Helicobacter heilmannii infection in C57/BL/6 mice

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Abstract.

Helicobacter heilmannii (Hh) has been clinically reported to have some relation to gastric low grade MALT lymphoma. Recently, we have formed the gastric MALT lymphoma in C57BL/6 mice.

Materials and methods:

C57BL/6 mice infected with Hh from cynomolgus monkey for more than 6 months were used. The macroscopic, immunohistochemical and electron microscopic observation was performed.

Results:

MALT lymphoma was formed in almost 100 % of the infected mice. Increased VEGF-A and Flt-3 immunoreactivity was recognized.

Conclusion:

Hh was shown to be related to the formation of MALT lymphoma and VEGF is suggested to play a role in this lymphoma.

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Authors and Affiliations

  1. Center for Clinical Pharmacy and Clinical Sciences, School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan

    M. Nakamura & K. Tsuchimoto

  2. Kitasato Institute for Life Sciences & Graduate School of Infection Control Sciences, Tokyo, Japan

    H. Matsui, S. Yamagata Murayama, T. Matsumoto & H. Yamada

  3. Graduate School of Pharmaceutical Science, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan

    H. Matsui & S. Yamagata Murayama

  4. Department of Internal Medicine, Kitasato Institute Hospital, The Kitasato Institute, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8642, Japan

    T. Matsumoto & H. Yamada

  5. 3rd Department of Internal Medicine, Kyorin University, Mitaka, Tokyo, 181-8611, Japan

    S. Takahashi

Authors
  1. M. Nakamura
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  2. H. Matsui
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  3. S. Yamagata Murayama
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  4. T. Matsumoto
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  5. H. Yamada
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  6. S. Takahashi
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  7. K. Tsuchimoto
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Corresponding author

Correspondence to M. Nakamura.

Additional information

Received 19 July 2006; revised 21 August 2006; accepted 28 August 2006

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Nakamura, M., Matsui, H., Murayama, S.Y. et al. Interaction of VEGF to gastric low grade MALT lymphoma by Helicobacter heilmannii infection in C57/BL/6 mice. Inflammopharmacol 15, 115–118 (2007). https://doi.org/10.1007/s10787-007-1549-5

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  • DOI: https://doi.org/10.1007/s10787-007-1549-5

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