Cavity-Enhanced Absorption Spectroscopy and Photoacoustic Spectroscopy for Human Breath Analysis
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This paper describes two different optoelectronic detection techniques: cavity-enhanced absorption spectroscopy and photoacoustic spectroscopy. These techniques are designed to perform a sensitive analysis of trace gas species in exhaled human breath for medical applications. With such systems, the detection of pathogenic changes at the molecular level can be achieved. The presence of certain gases (biomarkers), at increased concentration levels, indicates numerous human diseases. Diagnosis of a disease in its early stage would significantly increase chances for effective therapy. Non-invasive, real-time measurements, and high sensitivity and selectivity, capable of minimum discomfort for patients, are the main advantages of human breath analysis. At present, monitoring of volatile biomarkers in breath is commonly useful for diagnostic screening, treatment for specific conditions, therapy monitoring, control of exogenous gases (such as bacterial and poisonous emissions), as well as for analysis of metabolic gases.
KeywordsAbsorption spectroscopy Biomarker sensors Cavity-enhanced spectroscopy Gas sensors Laser drivers Laser spectroscopy Photoacoustic spectroscopy
These works were supported by the National Centre for Research and Development (research Project ID 179900) and the National Science Centre (research Project Nos. 2011/03/B/ST7/02544, O N515 216839, and O N515 217039).
- 2.H. O’Neill, S.M. Gordon, M. O’Neill, R.D. Gibbons, J.P. Szidon, Clin. Chem. 34, 1613 (1988)Google Scholar
- 4.J. Wojtas, Z. Bielecki, T. Stacewicz, J. Mikolajczyk, M. Nowakowski, Opto Electron. Rev. 201, 77 (2012)Google Scholar
- 5.A. Ulanowska, T. Ligor, M. Michel, B. Buszewski, Ecol. Chem. Eng. S 17, 9 (2010)Google Scholar
- 8.T. Stacewicz, J. Wojtas, Z. Bielecki, M. Nowakowski, J. Mikołajczyk, R. Mędrzycki, B. Rutecka, Opt. Electron. Rev. 20, 34 (2012)Google Scholar
- 10.Photonics Spectrum Reference Chart, Commercial Lasers Lines. Available to order: https://e.laurin.com/Default.aspx
- 17.A. Rogalski, Z. Bielecki, in Handbook of Optoelectronics, ed. by J. Dakin, R. Brown (Taylor & Francis, New York, 2006), pp. 73–117Google Scholar
- 19.Photonic Devices, Electron Tube Devices and Applied Products, 2012. http://sales.hamamatsu.com/assets/pdf/catsandguides/p-dev_2012_TOTH0020E02.pdf
- 21.A. Piotrowski, P. Madejczyk, W. Gawron, K. Klos, M. Romanis, M. Grudzien, A. Rogalski, J. Piotrowski, Opto Electron. Rev. 12, 453 (2004)Google Scholar