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Cavity-Enhanced Absorption Spectroscopy and Photoacoustic Spectroscopy for Human Breath Analysis

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Abstract

This paper describes two different optoelectronic detection techniques: cavity-enhanced absorption spectroscopy and photoacoustic spectroscopy. These techniques are designed to perform a sensitive analysis of trace gas species in exhaled human breath for medical applications. With such systems, the detection of pathogenic changes at the molecular level can be achieved. The presence of certain gases (biomarkers), at increased concentration levels, indicates numerous human diseases. Diagnosis of a disease in its early stage would significantly increase chances for effective therapy. Non-invasive, real-time measurements, and high sensitivity and selectivity, capable of minimum discomfort for patients, are the main advantages of human breath analysis. At present, monitoring of volatile biomarkers in breath is commonly useful for diagnostic screening, treatment for specific conditions, therapy monitoring, control of exogenous gases (such as bacterial and poisonous emissions), as well as for analysis of metabolic gases.

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Acknowledgments

These works were supported by the National Centre for Research and Development (research Project ID 179900) and the National Science Centre (research Project Nos. 2011/03/B/ST7/02544, O N515 216839, and O N515 217039).

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Authors and Affiliations

  1. Institute of Optoelectronics, Military University of Technology, 2 Kaliskiego Str., 00-908 , Warsaw, Poland

    J. Wojtas, Z. Bielecki, J. Mikolajczyk, M. Nowakowski & D. Szabra

  2. Electrical and Computer Engineering Department, Rice University, Houston, TX, 77005, USA

    F. K. Tittel, R. Lewicki, P. Stefanski & J. Tarka

  3. Institute of Experimental Physics, University of Warsaw, 69 Hoza Str., 00-681 , Warsaw, Poland

    T. Stacewicz

  4. Sentinel Photonics, 11 Deer Park Dr., STE 208, Monmouth Junction, NJ, 08852, USA

    R. Lewicki

  5. Laser and Fiber Electronics Group, Wroclaw University of Technology, 27 Wybrzeze Wyspianskiego Str., 50-370 , Wroclaw, Poland

    P. Stefanski & J. Tarka

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  1. J. Wojtas
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  2. F. K. Tittel
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  3. T. Stacewicz
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  4. Z. Bielecki
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  6. J. Mikolajczyk
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  7. M. Nowakowski
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  8. D. Szabra
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  10. J. Tarka
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Correspondence to J. Wojtas.

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Wojtas, J., Tittel, F.K., Stacewicz, T. et al. Cavity-Enhanced Absorption Spectroscopy and Photoacoustic Spectroscopy for Human Breath Analysis. Int J Thermophys 35, 2215–2225 (2014). https://doi.org/10.1007/s10765-014-1586-4

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  • DOI: https://doi.org/10.1007/s10765-014-1586-4

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