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Study of Tissue Phantoms, Tissues, and Contrast Agent with the Biophotoacoustic Radar and Comparison to Ultrasound Imaging for Deep Subsurface Imaging

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Abstract

In this study, the imaging capability of our wide-spectrum frequency-domain photoacoustic (FD-PA) imaging alias “photoacoustic radar” methodology for imaging of soft tissues is explored. A practical application of the mathematical correlation processing method with relatively long (1 ms) frequency-modulated optical excitation is demonstrated for reconstruction of the spatial location of the PA sources. Image comparison with ultrasound (US) modality was investigated to see the complementarity between the two techniques. The obtained results with a phased array probe on tissue phantoms and their comparison to US images demonstrated that the FD-PA technique has strong potential for deep subsurface imaging with excellent contrast and high signal-to-noise ratio. FD-PA images of blood vessels in a human wrist and an in vivo subcutaneous tumor in a rat model are presented. As in other imaging modalities, the employment of contrast agents is desirable to improve the capability of medical diagnostics. Therefore, this study also evaluated and characterized the use of Food and Drug Administration (FDA)-approved superparamagnetic iron oxide nanoparticles (SPION) as PA contrast agents.

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References

  1. Beard P.: Interface Focus 1, 602 (2011)

    Article  Google Scholar 

  2. Fan Y., Mandelis A., Spirou G., Vitkin I.A.: J. Acoust. Soc. Am. 116, 3523 (2004)

    Article  ADS  Google Scholar 

  3. Telenkov S.A., Mandelis A.: J. Biomed. Opt. 11, 044006 (2006)

    Article  ADS  Google Scholar 

  4. Telenkov S., Mandelis A., Lashkari B., Forcht M.: J. Appl. Phys. 105, 102029 (2009)

    Article  ADS  Google Scholar 

  5. Telenkov S.A., Mandelis A.: J. Biomed Opt. 14, 044025 (2009)

    Article  ADS  Google Scholar 

  6. Lashkari B., Mandelis A.: Rev. Sci. Instrum. 82, 094903 (2011)

    Article  ADS  Google Scholar 

  7. C.E. Cook, M. Bernfeld, Radar Signals: An Introduction to Theory and Application (Artech House, Norwood, MA, 1993)

  8. Telenkov S., Mandelis A.: Proc. SPIE 7899, 78990Y (2011)

    Article  ADS  Google Scholar 

  9. Ermilov S.A., Khamapirad T., Conjustau A., Leonard M., Lacewell R., Mehta K., Miller T., Oraevsky A.: J. Biomed. Opt. 14, 024007 (2009)

    Article  ADS  Google Scholar 

  10. Jose J., Manohar S., Kolkman R.G.M., Steenbergen W., van Leeuwen T.G.: J. Biophotonics 2, 701 (2009)

    Article  Google Scholar 

  11. Roggan A., Friebel M., Dorschel K., Hahn A., Muller G.: J. Biomed. Opt. 4, 36 (1999)

    Article  ADS  Google Scholar 

  12. Zhang H.F., Maslov K., Stoica G., Wang L.V.: Nat. Biotechnol. 24, 848 (2006)

    Article  Google Scholar 

  13. Spirou G.M., Oraevsky A.A., Vitkin I.A., Whelan W.M.: Phys. Med. Bio. 50, N141 (2005)

    Article  Google Scholar 

  14. J.E. Rosen, L. Chan, D.B. Shieh, F.X. Gu, Nanomedicine (2011). doi:10.1016/j.nano.2011.08.017

  15. Telenkov S., Alwi R., Mandelis A., Worthington A.: Opt. Lett. 36, 4560 (2011)

    Article  ADS  Google Scholar 

  16. Cheng F.Y., Su C.H., Yang Y.S., Yeh C.S., Tsai C.Y., Wu C.L., Wu M.T., Shieh D.B.: Biomaterials 26, 729 (2005)

    Article  Google Scholar 

  17. Luo B., Song X.J., Zhang F., Xia A., Yang W.L., Hu J.H., Wang C.C.: Langmuir 26, 1674 (2010)

    Article  Google Scholar 

  18. American National Standard, ANSI Z136.1-2007

  19. S.A. Telenkov, R. Alwi, A. Mandelis, submitted to Ultrason. Ferroelectr. Freq. Control

Download references

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Authors and Affiliations

  1. Center for Advanced Diffusion-Wave Technologies (CADIFT), Department of Mechanical Engineering, University of Toronto, 5 King’s College Road, Toronto, ON, M5S 3G8, Canada

    R. Alwi, S. Telenkov & A. Mandelis

  2. Department of Chemical Engineering, University of Waterloo, 200 University Avenue West, Waterloo, ON, N2L 3G1, Canada

    F. Gu

Authors
  1. R. Alwi
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  2. S. Telenkov
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  3. A. Mandelis
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  4. F. Gu
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Correspondence to A. Mandelis.

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Alwi, R., Telenkov, S., Mandelis, A. et al. Study of Tissue Phantoms, Tissues, and Contrast Agent with the Biophotoacoustic Radar and Comparison to Ultrasound Imaging for Deep Subsurface Imaging. Int J Thermophys 33, 1808–1813 (2012). https://doi.org/10.1007/s10765-012-1286-x

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  • DOI: https://doi.org/10.1007/s10765-012-1286-x

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