In vivo Non-invasive Diagnosis of Glucose Level in Type-2 Diabetes Mouse by THz Near-Field Imaging

  • Hua ChenEmail author
  • Yu Zhang
  • Xiao Li
  • Xiaofeng Chen
  • Shihua Ma
  • Xiumei Wu
  • Tianzhu Qiu
  • Weifeng Zhang


Based on a room-temperature-operated THz fiber-scanning near-field imaging system, we demonstrate in vivo the capability of THz imaging to directly diagnose blood glucose level non-invasively in a type-2 diabetes mouse. High THz absorption induced by higher glucose level facilitates the distinction of blood in mouse ear’s capillary from the surrounding tissues and the THz images reflect a high sensitivity to the change of glucose level in blood. The THz near-field imaging system presented here can have important potential applications in clinical non-invasive human diabetes examination.


THz Near-field imaging Diabetes mouse Blood Glucose level 



This work was supported by a Joint Research Project by Southeast University and Nanjing Medical University No. 3207027381 and China Postdoctoral Science Foundation No. 2016M601692.


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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.School of PhysicsSoutheast UniversityNanjingChina
  2. 2.The First Affiliated Hospital of Nanjing Medical UniversityNanjingChina

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