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Studying the Kinetics of n-Butyl-Cyanoacrylate Tissue Adhesive and Its Oily Mixtures

Abstract

This study deals with the measurement of the kinetics of tissue adhesives used for supporting the hemostasis and wound closure during surgical intervention. There are available several types of adhesives of different composition which is closely related with their application. When selecting an appropriate adhesive, the time of curing could play an important role because some applications may require very fast polymerization for prompt vessel or wound closure; conversely, some situations need slower solidification because of longer manipulation with the glue during surgery. The terahertz time-domain spectroscopy is used for studying the kinetics of the n-butyl-cyanoacrylate glue in this study. An oily substance is added to the glue samples to slow the reaction rate. The technique of attenuated total reflection is used in this application; the defined amount of glue sample or its mixture is applied on the silicon crystal and the terahertz response is measured in time. This time dependences are analyzed to find time constants for mathematical description of the glue kinetics. Further, the investigated samples were analyzed using light microscopy and Raman spectroscopy for description of the structures and compositions.

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Acknowledgments

This work was supported by the European Regional Development Fund under the project CEBIA-Tech Instrumentation No. CZ.1.05/2.1.00/19.0376 and by the internal excellence project “Technical Science for Secure Society”.

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Correspondence to Marie Nedvedova.

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Nedvedova, M., Kresalek, V., Vaskova, H. et al. Studying the Kinetics of n-Butyl-Cyanoacrylate Tissue Adhesive and Its Oily Mixtures. J Infrared Milli Terahz Waves 37, 1043–1054 (2016). https://doi.org/10.1007/s10762-016-0295-4

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Keywords

  • Glue kinetics
  • Oil
  • Raman spectroscopy
  • Terahertz time-domain spectroscopy
  • Tissue adhesive