Journal of Infrared, Millimeter, and Terahertz Waves

, Volume 37, Issue 10, pp 1043–1054

Studying the Kinetics of n-Butyl-Cyanoacrylate Tissue Adhesive and Its Oily Mixtures

  • Marie Nedvedova
  • Vojtech Kresalek
  • Hana Vaskova
  • Ivo Provaznik


This study deals with the measurement of the kinetics of tissue adhesives used for supporting the hemostasis and wound closure during surgical intervention. There are available several types of adhesives of different composition which is closely related with their application. When selecting an appropriate adhesive, the time of curing could play an important role because some applications may require very fast polymerization for prompt vessel or wound closure; conversely, some situations need slower solidification because of longer manipulation with the glue during surgery. The terahertz time-domain spectroscopy is used for studying the kinetics of the n-butyl-cyanoacrylate glue in this study. An oily substance is added to the glue samples to slow the reaction rate. The technique of attenuated total reflection is used in this application; the defined amount of glue sample or its mixture is applied on the silicon crystal and the terahertz response is measured in time. This time dependences are analyzed to find time constants for mathematical description of the glue kinetics. Further, the investigated samples were analyzed using light microscopy and Raman spectroscopy for description of the structures and compositions.


Glue kinetics Oil Raman spectroscopy Terahertz time-domain spectroscopy Tissue adhesive 

Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  1. 1.Faculty of Applied Informatics, Department of Electronics and MeasurementTomas Bata University in ZlinZlinCzech Republic
  2. 2.Faculty of Electrical Engineering and Communication, Department of Biomedical EngineeringBrno University of TechnologyBrnoCzech Republic

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