Studying the Kinetics of n-Butyl-Cyanoacrylate Tissue Adhesive and Its Oily Mixtures

  • Marie NedvedovaEmail author
  • Vojtech Kresalek
  • Hana Vaskova
  • Ivo Provaznik


This study deals with the measurement of the kinetics of tissue adhesives used for supporting the hemostasis and wound closure during surgical intervention. There are available several types of adhesives of different composition which is closely related with their application. When selecting an appropriate adhesive, the time of curing could play an important role because some applications may require very fast polymerization for prompt vessel or wound closure; conversely, some situations need slower solidification because of longer manipulation with the glue during surgery. The terahertz time-domain spectroscopy is used for studying the kinetics of the n-butyl-cyanoacrylate glue in this study. An oily substance is added to the glue samples to slow the reaction rate. The technique of attenuated total reflection is used in this application; the defined amount of glue sample or its mixture is applied on the silicon crystal and the terahertz response is measured in time. This time dependences are analyzed to find time constants for mathematical description of the glue kinetics. Further, the investigated samples were analyzed using light microscopy and Raman spectroscopy for description of the structures and compositions.


Glue kinetics Oil Raman spectroscopy Terahertz time-domain spectroscopy Tissue adhesive 



This work was supported by the European Regional Development Fund under the project CEBIA-Tech Instrumentation No. CZ.1.05/2.1.00/19.0376 and by the internal excellence project “Technical Science for Secure Society”.

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.


  1. 1.
    M. Ryou and C. C. Thompson, Tech. Gastrointest. Endosc. 8, 33–7 (2006)CrossRefGoogle Scholar
  2. 2.
    H. E. Achneck, B. Sileshi, R. M. Jamiolkowski, D. M. Albala, M. L. Shapiro and J. H. Lawson, Ann. Surg. 251, 217–28 (2010)CrossRefGoogle Scholar
  3. 3.
    S. K. Bhatia, Biomaterials for Clinical Applications (Springer, New York, 2010)CrossRefGoogle Scholar
  4. 4.
    P. A. Leggat, U. Kedjarune and D. R. Smith, Ind. Health 42, 207–11 (2004)CrossRefGoogle Scholar
  5. 5.
    A. Elaissari, Colloidal Biomolecules, Biomaterials, and Biomedical Applications (CRC Press, New York, 2003)CrossRefGoogle Scholar
  6. 6.
    A. J. Domb, J. Kost and D. Wiseman, Handbook of Biodegradable Polymers (CRC Press, Singapore, 1997)Google Scholar
  7. 7.
    D. C. Suh, H. B. Shi, S. S. Park, M. S. Lee and H. Y. Choi, Am. J. Neuroradiol. 21, 1277–9 (2000)Google Scholar
  8. 8.
    M. J. Gounis, B. B. Lieber, A. K. Wakhloo, R. Siekmann and L. N. Hopkins, Am. J. Neuroradiol. 23, 938–44 (2002)Google Scholar
  9. 9.
    X. Yin, B. W.-H. Ng and D. Abbott, Terahertz Imaging for Biomedical Applications (Springer, New York, 2012)CrossRefGoogle Scholar
  10. 10.
    L. P. Choo-Smith, H. G. Edwards, H. P. Endtz, J. M. Kros, F. Heule, H. Barr, J. S. Robinson Jr, H. A. Bruining and G. J. Puppels, Biopolymers 67, 1–9 (2002)CrossRefGoogle Scholar
  11. 11.
    Y. J. Lee, G. B. Jung, S. Choi, G. Lee, J. H. Kim, H. S. Son, H. Bae and H. K. Park, PLoS One 8, 1–9 (2013)CrossRefGoogle Scholar
  12. 12.
    D. A. Newnham and P. F. Taday, Appl. Spectrosc. 62, 394–8 (2008)CrossRefGoogle Scholar
  13. 13.
    Histoacryl®, Prescribing Information. Rubí, Spain: B. Braun Surgical, 2013.Google Scholar
  14. 14.
    N. Kawai, M. Sato, H. Minamiguchi, A. Ikoma, H. Sanda, K. Nakata, F. Tanaka, M. Nakai and T. Sonomura, J. Vasc. Interv. Radiol. 23, 1516–21 (2012)CrossRefGoogle Scholar
  15. 15.
    F. N. Elmasalme, S. A. Matbouli and M. S. Zuberi, J. Pediatr. Surg. 30, 837–8 (1995)CrossRefGoogle Scholar
  16. 16.
    M. Mehdizadeh and J. Yang, Macromol. Biosci. 13, 271–88 (2013)CrossRefGoogle Scholar
  17. 17.
    C. B. Giray, A. Atasever, B. Durgun and K. Araz, Aust. Dent. J. 42, 255–8 (1997)CrossRefGoogle Scholar
  18. 18.
    B. Freitag, R. Sroka, S. Koelle, A. J. Becker, W. Khoder, T. Pongratz, C. G. Stief and M. Trottmann, Proc. SPIE 8926 (San Francisco: SPIE Digital Library) p 1–3 (2014)Google Scholar
  19. 19.
    K. Kotzampassi and E. Eleftheriadis, Surgery 157, 79–86 (2015)CrossRefGoogle Scholar
  20. 20.
    K. A. Vakalopoulos, F. Daams, Z. Wu, L. Timmermans, J. J. Jeekel, G. J. Kleinrensink, A. van der Ham and J. F. Lange, J. Surg. Res. 180, 290–300 (2013)CrossRefGoogle Scholar
  21. 21.
    S. Alkan, B. Dadaş, D. Celik, B. U. Coskun, F. Yilmaz and T. Başak, Eur. Arch. Otorhinolaryngol. 264, 1425–30 (2007)CrossRefGoogle Scholar
  22. 22.
    S. Barbosa, T. Nieves, F. García, E. Cepeda, X. Moll, A. Marco, C. Weis, P. Turon and P. Vergara, Biomed. Res. Int. 2015, 1–9 (2015)Google Scholar
  23. 23.
    M. Sovak, Radiocontrast Agents (Springer, Berlin Heidelberg, 1984)CrossRefGoogle Scholar
  24. 24.
    K. J. Kolbeck, J. Vasc. Interv. Radiol. 22, 419–20 (2011)CrossRefGoogle Scholar
  25. 25.
    Histoacryl®, Safety Data Sheet. Tuttlingen, Germany: AESCULAP AG & CO. KG, 2004.Google Scholar
  26. 26.
    F. Shahidi, Bailey’s Industrial Oil and Fat Products (John Wiley & Sons, New Jersey, 2005).CrossRefGoogle Scholar
  27. 27.
    M. Bockisch, Fats and Oils Handbook (AOCS Press, Illinois, 1998)Google Scholar
  28. 28.
    C. Takasawa, K. Matsunaga, K. Seiji, T. Mastuhashi, S. Shida, M. Ota, Y. Nakamura, F. Fujishima, S. Takahashi, ECR 2011 / C-1509, p 1–17 (2011)Google Scholar
  29. 29.
    T. Probst, S. Sommer, A. Soltani, E. Kraus, B. Baudrit, G. E. Town and M. Koch, J. Infrared Milli. Terahz. Waves 36, 569–577 (2015)CrossRefGoogle Scholar
  30. 30.
    P. Atkins, J. de Paula and R. Friedman, Quanta, Matter, and Change: A Molecular Approach to Physical Chemistry (Oxford University Press, Oxford, 2009)Google Scholar

Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  1. 1.Faculty of Applied Informatics, Department of Electronics and MeasurementTomas Bata University in ZlinZlinCzech Republic
  2. 2.Faculty of Electrical Engineering and Communication, Department of Biomedical EngineeringBrno University of TechnologyBrnoCzech Republic

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