Abstract
In this paper, we have studied terahertz (THz) pulse time delay of porous pharmaceutical microcrystalline compacts and also pharmaceutical tablets that contain indomethacin (painkiller) as an active pharmaceutical ingredient (API) and microcrystalline cellulose as the matrix of the tablet. The porosity of a pharmaceutical tablet is important because it affects the release of drug substance. In addition, surface roughness of the tablet has much importance regarding dissolution of the tablet and hence the rate of drug release. Here, we show, using a training set of tablets containing API and with a priori known tablet’s quality parameters, that the effective refractive index (obtained from THz time delay data) of such porous tablets correlates with the average surface roughness of a tablet. Hence, THz pulse time delay measurement in the transmission mode provides information on both porosity and the average surface roughness of a compact. This is demonstrated for two different sets of pharmaceutical tablets having different porosity and average surface roughness values.
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References
K.-E. Peiponen, R. Myllylä, A.V. Priezzhev, Optical Measurement Techniques: Innovations for Industry and Life Sciences (Springer, Berlin, 2009).
PAT—A Framework for Innovative Pharmaceutical Development, Manufacturing, and Quality Assurance. (FDA 2004), http://www.fda.gov/downloads/Drugs/Guidances/ucm070305.pdf. Accessed 14 November 2015.
A. Kauppinen, M. Toiviainen, J. Aaltonen, O. Korhonen, K. Järvinen, M. Juuti, R. Pellinen, J. Ketolainen, Anal. Chem. 85, 2109-2116 (2013).
J.A. Zeitler, Y.-C. Shen, in Terahertz Spectroscopy and Imaging, ed. By K.-E. Peiponen, J.A. Zeitler, M. Kuwata-Gonokami (Springer, Berlin, 2013), p. 451-459.
C.J. Strachan, T. Rades, D. Newnham, K.C. Gordon, M. Pepper, P.F. Taday, Chem. Phys. Lett. 390, 20-20 (2004).
H. Wu, E.J. Heilweil, A.S. Hussain, M.A. Khan, Int. J. Pharm. 343, 148-158 (2007).
G. Alderborn, Pharmaceutics the Science of Dosage Form Design, 2nd edn. (Churchill Livingstone, Edinburgh, 2002).
A. Halenius, S. Lakio, O. Antikainen, J. Hatara, J. Yliruusi, AAPS PharmSciTech 15, 781-790 (2014).
P. Bawuah, A. Pierotic Mendia, P. Silfsten, P. Pääkkönen, T. Ervasti, J. Ketolainen, J.A. Zeitler, K.-E. Peiponen, Int. J. Pharm. 465, 70-76 (2014).
T. Ervasti, P. Silfsten, J. Ketolainen, K.-E. Peiponen, Appl. Spectrosc. 66, 319-323 (2012).
T. Shibata, T. Mori, S. Kojima, Spectrochim. Acta A 150, 207-211 (2015).
P. U. Jepsen, D. G. Cooke, M. Koch, Laser Photonics Rev. 5, 124-166 (2011).
Y.-C. Shen, Int. J. Pharm. 417, 48-60 (2011).
L.M. Zurk, S. Scheckman, in Terahertz Spectroscopy and Imaging, ed. By K.-E. Peiponen, J.A. Zeitler, M. Kuwata-Gonokami (Springer, Berlin, 2013), p. 95-115.
A. Jagannathan, A. J. Gatesman,R. H. Giles, Opt. Lett. 34, 1927-1929 (2009).
P. Beckmann an A. Spizzichino, Scattering of Electromagnetic Waves from Rough Surfaces (Pergamon, Oxford, 1963).
E. P. J. Parrott, J. A. Zeitler, L. F. Gladden, Opt. Lett. 34, 3722-3724 (2009).
R. Silvennoinen, V. Hyvärinen, P. Raatikainen, K.-E. Peiponen, Int. J. Pharm. 199, 205-208 (2000).
E. O. Kissi, P. Bawuah, P. Silfste, K.-E. Peiponen, J. Infrared Milli. Terahz. Waves, 36, 278-290 (2015).
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Chakraborty, M., Bawuah, P., Tan, N. et al. On the Correlation of Effective Terahertz Refractive Index and Average Surface Roughness of Pharmaceutical Tablets. J Infrared Milli Terahz Waves 37, 776–785 (2016). https://doi.org/10.1007/s10762-016-0262-0
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DOI: https://doi.org/10.1007/s10762-016-0262-0