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Supplementing Glucose Intake Reverses the Inflammation Induced by a High-Fat Diet by Increasing the Expression of Siglec-E Ligands on Erythrocytes

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Abstract

Siglec-9/E is a cell surface receptor expressed on immune cells and can be activated by sialoglycan ligands to play an immunosuppressive role. Our previous study showed that increasing the expression of Siglec-9 (the human paralog of mouse Siglec-E) ligands maintains functionally quiescent immune cells in the bloodstream, but the biological effects of Siglec-9 ligand alteration on atherogenesis were not further explored. In the present study, we demonstrated that the atherosclerosis risk factor ox-LDL or a high-fat diet could decrease the expression of Siglec-9/E ligands on erythrocytes. Increased expression of Siglec-E ligands on erythrocytes caused by dietary supplementation with glucose (20% glucose) had anti-inflammatory effects, and the mechanism was associated with glucose intake. In high-fat diet-fed apoE−/− mice, glucose supplementation decreased the area of atherosclerotic lesions and peripheral inflammation. These data suggested that increased systemic inflammation is attenuated by increasing the expression of Siglec-9/E ligands on erythrocytes. Therefore, Siglec-9/E ligands might be valuable targets for atherosclerosis therapy.

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The data of this study may be available on reasonable request to the corresponding author.

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Funding

This work was supported by the National Natural Science Foundation of China (No. 81973319, 81673427) and the Chongqing Research Program of Natural Science (No. cstc2019jcyj-msxmX0372).

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  1. Hongmei Liu and Jin Li contributed equally to this work.

Authors and Affiliations

  1. Institute of Materia Medica and Department of Pharmaceutics, College of Pharmacy, Army Medical University, Chongqing, 400038, China

    Hongmei Liu, Jin Li, Niting Wu, Yadan Luo, Yan Huang, Hongyu Quan, Wenying Fu, Xiaohui Li & Yi Jia

  2. Department of Haematology, Daping Hospital of Army Medical University, Chongqing, 400042, China

    Yuanting She & Dongfeng Zeng

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Yi Jia and Dongfeng Zeng designed the study. Hongmei Liu and Jin Li analyzed the data and wrote the manuscript. Hongmei Liu, Yuanting She and Wenying Fu performed the animal experiments. Jin Li, Niting Wu and Hongyu Quan performed the cell experiments. Yadan Luo and Yan Huang performed the ion-paired HPLC analysis. Jin Li and Niting Wu collected the clinical samples. Yi Jia, Dongfeng Zeng and Xiaohui Li revised the manuscript.

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Liu, H., Li, J., Wu, N. et al. Supplementing Glucose Intake Reverses the Inflammation Induced by a High-Fat Diet by Increasing the Expression of Siglec-E Ligands on Erythrocytes. Inflammation (2024). https://doi.org/10.1007/s10753-023-01932-0

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