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Inhibitory Effect of Oroxylin A in a Mouse Model of Atopic Dermatitis

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Abstract

Scutellaria baicalensis has long been used in Asian traditional medicine to prevent and treat suppurative dermatitis, allergic diseases, inflammation, hyperlipemia, and arteriosclerosis. Oroxylin A is a flavone present in Scutellaria baicalensis. Because the root extracts of Scutellaria baicalensis have been shown to have anti-dermatitis effects, the authors investigated the effects of oroxylin A on chemically induced atopic dermatitis (AD) in an in vivo AD model induced by 1-chloro-2,4-dinitrobenzene (CDNB) in BALB/c mice. CDNB-induced skin hypertrophy and accumulation of mast cells in the epidermis and dermis were significantly decreased by oroxylin A. Increased serum levels of immunoglobulin E, as well as pro-inflammatory chemokines and cytokines in the skin and lymph nodes, were significantly decreased by oroxylin A. Suppression of immune responses in the skin and lymph nodes by oroxylin A decreased the symptoms of AD. Thus, these results proved that oroxylin A is an effective component of Scutellaria baicalensis for treating the symptoms of AD.

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Funding

This research was supported by the Basic Research Laboratory Program (BRL) and the Basic Science Research Program of the Korean National Research Foundation funded by the Korean Ministry of Science, ICT and Future Planning (NRF-2020R1A4A1016142 and NRF-2019R1A2C1005523).

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Authors and Affiliations

  1. Department of Basic Pharmaceutical Science, Graduate School, College of Pharmacy, Kyung Hee University, Seoul, 02447, Republic of Korea

    Ye-Ji Lee & Dong-Soon Im

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  1. Ye-Ji Lee
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Contributions

YJ Lee and DS Im designed the experiments. YJ Lee performed the experiments and analyzed the data. YJ Lee and DS Im wrote the manuscript.

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Correspondence to Dong-Soon Im.

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Lee, YJ., Im, DS. Inhibitory Effect of Oroxylin A in a Mouse Model of Atopic Dermatitis. Inflammation 46, 679–687 (2023). https://doi.org/10.1007/s10753-022-01764-4

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  • DOI: https://doi.org/10.1007/s10753-022-01764-4

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