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Targeting Oxidative Stress Markers, Xanthine Oxidase, TNFRSF11A and Cathepsin L in Curcumin-Treated Collagen-Induced Arthritis: A Physiological and COSMO-RS Study

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Abstract

The effectiveness of curcumin in preventing and treating collagen-induced inflammatory arthritis (CIA) in rats and oxidative stress in rats was investigated. We investigated curcumin’s curative and preventive effects on paw edema, arthritic size, body weight, and radiologic and histological joint abnormalities. It has been shown that curcumin may dramatically lower the risk of developing arthritis. In addition, the number of white blood cells (WBCs) in the body has dropped, which is a strong indication that curcumin has anti-inflammatory characteristics. A follow-up theoretical investigation of curcumin molecular docking on xanthine oxidase (XO) was carried out after the properties of curcumin were determined using the conductor-like screening model for real solvents (COSMO-RS) theory. Because of the interaction between curcumin and the residues on XO named Ile264, Val259, Asn351, and Leu404, XO may be suppressed by this molecule. Curcumin’s anti-inflammatory and antioxidant properties may be responsible for the anti-arthritic effects that have been seen on oxidative stress markers and XO. On the other hand, more research is being conducted to understand its function better in the early stages of rheumatoid arthritis (RA). To determine whether or not curcumin interacts with AR targets, a molecular docking study was conducted using MVD software against TNFRSF11A and cathepsin L.

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Acknowledgements

The authors would like to extend their sincere appreciation to the Researchers Supporting Project Number (RSP2022R457), King Saud University, Riyadh, Saudi Arabia.

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Seghira Bisset, Widad Sobhi, Rezgui, Siham Ferdjioui, Yacine Derradji, and Abdelhalim Khenchouche contributed to the study conception and design, material preparation, data collection, and analysis. Conceptualization, supervision, and data analysis were performed by Seghira Bisset and Widad Sobhi. The docking study was done by Ayoub Attoui and Khalil Errahmane Kanouni. The first draft of the manuscript was written by all authors. Tarek Lamaoui, Manawwer Alam, and Yacine Benguerba contributed to the writing and editing of the article. All authors read and approved the final manuscript. Yousef A. Bin Jardan actively contributed to the editing and response to the reviewers’ comments. Shobhan Das contributed to improving the English and helped to respond to reviewers’ comments.

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Correspondence to Widad Sobhi or Yacine Benguerba.

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The animal experimental protocol reported in the study was approved by the Institutional Animal Ethics Committee (IAEC) of the University Ferhat Abbas Setif 1, Setif, Algeria.

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The authors declare no competing interests.

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Bisset, S., Sobhi, W., Attoui, A. et al. Targeting Oxidative Stress Markers, Xanthine Oxidase, TNFRSF11A and Cathepsin L in Curcumin-Treated Collagen-Induced Arthritis: A Physiological and COSMO-RS Study. Inflammation 46, 432–452 (2023). https://doi.org/10.1007/s10753-022-01745-7

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