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Low Urine Secretion of Semaphorin3A in Lupus Patients with Proteinuria

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Abstract

Immune semaphorins are important in controlling both innate and adaptive immune responses. The regulatory role of semaphorin3A (sema3A) in systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and other autoimmune diseases is widely reported. Decreased levels of serum sema3A were shown to correlate with SLE disease activity. The aim was to assess urine concentrations of sema3A in SLE patients and its correlation with renal involvement and disease activity. Urine levels of sema3A were analyzed in 38 SLE patients, 13 with renal involvement, and were compared to 10 healthy volunteers and 8 RA patients (disease control group). The excretion of urine sema3A was found to be significantly lower in SLE patients compared to healthy volunteers and RA patients (4.9 ± 3.9 ng/ml, 8.5 ± 2.7 ng/ml, 9.85 ± 1.7 ng/ml, respectively, p = 0.0006). Urine sema3A was significantly lower in SLE patients with lupus nephritis than in patients without nephritis (4.0 ± 3.4 ng/ml vs. 6.5 ± 3.8 ng/ml, p = 0.03). Urine sema3A inversely correlated with proteinuria and SLE disease activity. Urine sema3A is decreased in lupus patients and should be further evaluated as a possible biomarker for disease activity and renal involvement.

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Author notes

  1. Rimar Doron and Lidar Merav contributed equally.

Authors and Affiliations

  1. Department of Rheumatology, Bnai-Zion Medical Center, Haifa, Israel

    Rimar Doron, Slobodin Gleb, Rosner Itzhak & Rozenbaum Michael

  2. Unit of Rheumatology, Sheba Medical Center, Ramat Gan, Israel

    Lidar Merav

  3. Division of Allergy & Clinical Immunology, Technion- Rappaport Faculty of Medicine, the Proteomic and Flow-Cytometry Unit, Bnai-Zion Medical Center, Haifa, Israel

    Eiza Nasrin, Sabag D Adi, Toubi Elias & Vadasz Zahava

Authors
  1. Rimar Doron
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  2. Lidar Merav
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  3. Eiza Nasrin
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  4. Sabag D Adi
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  5. Toubi Elias
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  6. Slobodin Gleb
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  8. Rozenbaum Michael
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  9. Vadasz Zahava
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All the authors contributed to the manuscript and reviewed and approved it as presented here.

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Correspondence to Rimar Doron.

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Doron, R., Merav, L., Nasrin, E. et al. Low Urine Secretion of Semaphorin3A in Lupus Patients with Proteinuria. Inflammation 45, 603–609 (2022). https://doi.org/10.1007/s10753-021-01570-4

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  • DOI: https://doi.org/10.1007/s10753-021-01570-4

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