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Selenium-Containing Compound Ameliorates Lipopolysaccharide-Induced Acute Lung Injury via Regulating the MAPK/AP-1 Pathway

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Abstract—Acute lung injury (ALI) is characterized by a series of inflammatory reactions and serves as the main cause of mortality in intensive care unit patients. Although great progress has been made in understanding the pathophysiology of ALI, there are no effective treatments in clinic. Recently, we have synthesized a selenium-containing compound, which possesses obvious anti-inflammatory activity. The aim of the present study is to evaluate the protective effects of the selenium-containing compound 34# in LPS-induced ALI in mice as well as its underlying mechanism. Compound 34# was found to inhibit LPS-induced macrophage inflammatory cytokine release. These effects were observed to be produced via suppression of the MAPK/AP-1 pathway. Compound 34# was also noted to attenuate the LPS-induced lung inflammation in mice with ALI. The corresponding results suggested that compound 34# possesses remarkable protective effects on LPS-induced ALI. Furthermore, the MAPK/AP-1 pathway may prove to be the underlying mechanism. Accordingly, compound 34# may serve as a potential candidate for the prevention of ALI.

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Acknowledgements

We would like to give our sincere gratitude to the reviewers for their constructive comments.

Funding

This study was supported by the Wenzhou Scientific and Technology Program (Y2020174), National College Student Innovation and Entrepreneurship Training Program (202010343011), and Wenzhou Medical University Scientific Research Projects of College Students (wyx2020101027).

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Author notes

  1. Wenjing Jia and Wenting Ding authors contribute equally to this work.

Authors and Affiliations

  1. Medicine and Health Care Center, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325035, Zhejiang, China

    Wenjing Jia, Yali Zhang & Zaisheng Zhu

  2. Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, Zhejiang, China

    Wenjing Jia, Wenting Ding, Xinmiao Chen, Zhengwei Xu, Yelin Tang, Meihong Wang, Bin Zheng, Yali Zhang & Tao Wei

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  1. Wenjing Jia
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Contributions

Data curation, Zaisheng Zhu, Wenjing Jia; formal analysis, Wenjing Jia; funding acquisition, Wenting Ding and Zaisheng Zhu; methodology, Wenjing Jia, Yali Zhang and Xinmiao Chen; validation, Meihong Wang, Zhengwei Xu, and Yelin Tang; visualization, Bin Zheng and Xinmiao Chen; writing — original draft, Wenjing Jia; writing—review and editing, Tao Wei and Zaisheng Zhu.

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Correspondence to Tao Wei or Zaisheng Zhu.

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Jia, W., Ding, W., Chen, X. et al. Selenium-Containing Compound Ameliorates Lipopolysaccharide-Induced Acute Lung Injury via Regulating the MAPK/AP-1 Pathway. Inflammation 44, 2518–2530 (2021). https://doi.org/10.1007/s10753-021-01521-z

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