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Ameliorative Effects of Oleuropein on Lipopolysaccharide-Induced Acute Lung Injury Model in Rats

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Abstract

Acute lung injury (ALI) is one of the most common causes of death in diseases with septic shock. Oleuropein, one of the important components of olive leaf, has antioxidant and anti-inflammatory effects. The objective of this study was to investigate the effects of oleuropein on lipopolysaccharide (LPS)-induced ALI in rats. Oleuropein was administered to rats at a dose of 200 mg/kg for 20 days and LPS was given through intratracheal administration to induce ALI. The study was terminated after 12 h. The results showed that in the group treated with oleuropein, inflammatory cytokines and oxidative stress decreased in serum, bronchoalveolar lavage fluid (BALF), and lung tissue, and there were significant improvements in the picture of acute interstitial pneumonia (AIP) caused by LPS in histopathological examination. Based on the findings of the present study, oleuropein showed protective effects against LPS-induced ALI.

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Data Availability

The data used to support the findings of this study are available from the corresponding author on reasonable request.

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Funding

This study was financially supported by the Scientific Research Projects Coordination of Hatay Mustafa Kemal University (project number: 20.M.020).

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Authors and Affiliations

  1. Department of Chest Diseases, Faculty of Medicine, University of Hatay Mustafa Kemal, 31060, Antakya, Hatay, Turkey

    Nursel Dikmen

  2. Department of Physiology, Faculty of Veterinary Medicine, University of Hatay Mustafa Kemal, Antakya, Hatay, Turkey

    Mustafa Cellat, Muhammed Etyemez & Mehmet Güvenç

  3. Department of Surgery, Faculty of Veterinary Medicine, University of Hatay Mustafa Kemal, Antakya, Hatay, Turkey

    Cafer Tayer İşler

  4. Department of Pathology, Faculty of Veterinary Medicine, University of Hatay Mustafa Kemal, Antakya, Hatay, Turkey

    Ahmet Uyar

  5. Department of Pharmacognosy, Faculty of Pharmacy, Ağrı İbrahim Çeçen University, Agri, Turkey

    Tuba Aydın

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  1. Nursel Dikmen
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Contributions

ND: project administration, funding acquisition, methodology, conceptualization, writing—review and editing, supervision. MG: methodology, formal analysis, investigation, writing—original draft. AU: methodology, formal analysis, resources, investigation. MC: validation, resources, investigation. CTİ: formal analysis, resources, investigation. TA: formal analysis, validation, investigation. ME: methodology, visualization, investigation.

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Correspondence to Nursel Dikmen.

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This study was approved by Hatay Mustafa Kemal University Animal Experiments Local Ethics Committee (approval no. 2020/02-17).

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Dikmen, N., Cellat, M., Etyemez, M. et al. Ameliorative Effects of Oleuropein on Lipopolysaccharide-Induced Acute Lung Injury Model in Rats. Inflammation 44, 2246–2259 (2021). https://doi.org/10.1007/s10753-021-01496-x

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