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Inflammation

, Volume 40, Issue 3, pp 904–912 | Cite as

Anti-inflammatory Role of Pilose Antler Peptide in LPS-Induced Lung Injury

  • Chunhua Ma
  • Hongyan LongEmail author
  • Chunhui Yang
  • Wenjun Cai
  • Tianzhu ZhangEmail author
  • Wenhai Zhao
ORIGINAL ARTICLE

Abstract

The present study was designed to investigate the effects of pilose antler peptide (PAP) on lipopolysaccharide (LPS)-induced lung injury. BalB/c mice intraperitoneally received PAP (10 and 20 mg/kg) or dexamethasone (2 mg/kg) 1 h prior to intratracheal instillation of LPS. PAP significantly decreased lung wet-to-dry weight (W/D) ratio and lung myeloperoxidase (MPO) activity and restored LPS-induced lung histopathological changes. PAP also increased super oxide dismutase (SOD) level and inhibited malondialdehyde (MDA) content and levels of pro-inflammatory cytokines including tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) in bronchoalveolar lavage fluid (BALF) in LPS-stimulated mice. Furthermore, we demonstrated that PAP inhibited Rho/NF-κB pathway in LPS-induced mice. Our experimental results indicated that the protective mechanism of PAP might be attributed partly to the inhibition of Rho/NF-κB pathway.

KEY WORDS

pilose antler peptide LPS lung injury Rho/NF-κB 

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  1. 1.Central Laboratory, Nanjing Municipal Hospital of T.C.MThe Third Affiliated Hospital of Nanjing University of T.C.MNanjingChina
  2. 2.The First Affiliated Hospital of Changchun University of Chinese MedicineChangchunChina
  3. 3.Changchun University of Chinese MedicineChangchunChina

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