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Effects of Acetylsalicylic Acid Usage on Inflammatory and Oxidative Stress Markers in Hemodialysis Patients

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Abstract

The aims of this study were to determine the effects of acetylsalicylic acid (ASA) on inflammation and oxidative stress markers in hemodialysis (HD) patients and to examine the associations between these markers and the sociodemographic and clinical characteristics of participants. The study included 36 subjects who used 300 mg of ASA for 60 days. Inflammation and oxidative stress were assessed based on levels of biochemical markers. ASA usage promoted a decrease in high-sensitivity C-reactive protein (p = 0.01). The level of hydrogen peroxide increased after 30 days of use of ASA and subsequently decreased (p = 0.01). Reduced glutathione reduced at the end of the study (p < 0.01); the malondialdehyde level did not change and the levels of vitamins A and E were inverse to drug use (p = 0.01). ASA usage promoted reduced levels of inflammation, increased production of markers of oxidative stress, and reduced antioxidant defense.

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References

  1. Jofré, R., P. Rodriguez-Benitez, J.M. López-Gómez, and R. Pérez-Garcia. 2006. Inflammatory syndrome in patients on hemodialysis. Journal of the American Society of Nephrology 17: 274–280.

    Article  Google Scholar 

  2. Ajala, M.O., P.S. Ogunro, and A. Odun. 2011. Effect of hemodialysis on total antioxidant status of chronic renal failure patients in government hospitals in Lagos Nigeria. Nigerian Journal of Clinical Practice 14: 154–158.

    Article  CAS  PubMed  Google Scholar 

  3. Vecchi, A.F., F. Bamonti, C. Novembrino, et al. 2009. Free and total plasma malondialdehyde in chronic renal insufficiency and in dialysis patients. Nephrology, Dialysis, Transplantation 24: 2524–2529.

    Article  PubMed  Google Scholar 

  4. Abahusain, M.A., and N.N. Al-Nahedh. 2002. The biochemical status of vitamin A and alpha-tocopherol during different stages of renal disease and its relationship to diabetes. Saudi Journal of Kidney Diseases and Transplantation 13: 18–23.

    PubMed  Google Scholar 

  5. Santangelo, F., V. Witko-Sarsat, T. Drüeke, and B. Descamps-Latscha. 2004. Restoring glutathione as a therapeutic strategy in chronic kidney disease. Nephrology, Dialysis, Transplantation 19: 1951–1955.

    Article  CAS  PubMed  Google Scholar 

  6. Montazerifar, F., M. Hashemi, M. Karajibani, and M. Dikshit. 2010. Hemodialysis alters lipid profiles, total antioxidant capacity, and vitamins A, E, and C concentrations in humans. Journal of Medicinal Food 13: 1490–1493.

    Article  CAS  PubMed  Google Scholar 

  7. Menon, V., T. Greene, X. Wang, et al. 2005. C-reactive protein and albumin as predictors of all-cause and cardiovascular mortality in chronic kidney disease. Kidney International 68: 766–772.

    Article  CAS  PubMed  Google Scholar 

  8. Bergstrom, J., and B. Lindholm. 1998. Malnutrition, cardiac disease, and mortality: an integrated point of view. American Journal of Kidney Diseases 32: 834–841.

    Article  CAS  PubMed  Google Scholar 

  9. Zyga, S., C.A. Hutchison, S. Stringer, et al. 2014. Inflammation and endothelial dysfunction in the initiation and propagation of cardiovascular disease in patients with chronic kidney disease. British Journal of Medical Research 4: 2568–2580.

    Article  Google Scholar 

  10. Sundaram, S.P.M., S. Nagarajan, and A.J.M. Devi. 2014. Chronic kidney disease—effect of oxidative stress. Chinese Journal of Biology 2014: 1–6.

    Article  Google Scholar 

  11. Wali, R.K. 2010. Aspirin and the prevention of cardiovascular disease in chronic kidney disease. Journal of the American College of Cardiology 56: 966–968.

    Article  CAS  PubMed  Google Scholar 

  12. Sociedade Brasileira de Cardiologia. 2013. Diretrizes brasileiras de antiagregantes plaquetários e anticoagulantes em cardiologia. Arquivos Brasileiros de Cardiologia 101: 1–95.

    Article  Google Scholar 

  13. Antiplatelet Trialists’ Collaboration. 1994. Bulário Eletrônico: Aspirina [internet]. Brasília: Ministério da Saúde. Agência Nacional de Vigilância Sanitária (ANVISA) 2009. British Medical Journal 308: 81-106. Available at: http://www4.anvisa.gov.br/base/visadoc/BM/BM[25345-1-0].PDF [Date accessed: 7 January 2013]

  14. Kalantar-Zadeh, K., J.D. Kopple, G. Block, and M.H. Humphreys. 2001. A malnutrition-inflammation score is correlated with morbidity and mortality in maintenance hemodialysis patients. American Journal of Kidney Diseases 38: 1251–1263.

    Article  CAS  PubMed  Google Scholar 

  15. Roberts, W.L., R. Sedrick, L. Moulton, A. Spencer, and N. Rifai. 2000. Evaluation of four automated high-sensitivity C-reactive protein methods: implications for clinical and epidemiological applications. Clinical Chemistry 46: 461–468.

    CAS  PubMed  Google Scholar 

  16. Södergren, E. et al. 1998. Re-evaluation of the ferrous oxidation in xylenol orange assay for the measurement of plasma lipid hydroperoxides. Journal of Biochemical and Biophysical Methods 37: 137–146.

  17. Nourooz-Zadeh, J., J. Tajaddini-Sarmadi, and S.P. Wolff. 1994. Measurement of plasma hydroperoxide concentrations by the ferrous oxidation-xylenol orange assay in conjunction with triphenylphosphine. Analytical Biochemistry 220: 403–9.

    Article  CAS  PubMed  Google Scholar 

  18. Galli, F., M. Piroddi, C. Annetti, C. Aisa, E. Floridi, and A. Floridi. 2005. Oxidative stress and reactive oxygen species. Contributions to Nephrology 149: 240–60.

    Article  CAS  PubMed  Google Scholar 

  19. Gerard-Monnier, D., I. Erdelmeier, K. Régnard, N. Moze-Henry, J.C. Yadan, and J. Chaudière. 1998. Reactions of 1-methyl-2-phenylindole with malondialdehyde and 4-hydroxyalkenals. Analytical applications to a colorimetric assay of lipid peroxidation. Chemical Research in Toxicology 11: 1176–83.

    Article  CAS  PubMed  Google Scholar 

  20. Ellman, G.L. 1959. Tissue sulfhydryl groups. Archives of Biochemistry and Biophysics 82: 70–7.

    Article  CAS  PubMed  Google Scholar 

  21. Hu, M.L. 1994. Measurement of protein thiol groups and glutathione in plasma. Methods in Enzymology 233: 380–5.

    Article  CAS  PubMed  Google Scholar 

  22. Arnaud, J., I. Fortis, S. Blachier, D. Kia, and A. Favier. 1991. Simultaneous determination of retinol, alpha-tocopherol and beta-carotene in serum by isocratic high-performance liquid chromatography. Journal of Chromatography 572: 103–16.

    Article  CAS  PubMed  Google Scholar 

  23. Huang, Y., Y. Zhong, X. Ding, et al. 2011. Aspirin can reduce serum C reactive protein level in maintenance hemodialysis patients. Chinical Journal of Nephrology 27: 271–275.

    CAS  Google Scholar 

  24. Waterman, M., B. Fuhrman, S. Keidar, and T. Hayek. 2009. Aspirin promotes low density lipoprotein susceptibility to oxidative modification in healthy volunteers. The Israel Medical Association Journal 11: 730–734.

    PubMed  Google Scholar 

  25. Selvakumar, C., U. Maheshwari, X. Suganthi, and X. Archana. 2012. Oxidant-antioxidant disturbance in men classified as obese according to the preliminary WHO guidelines for Asians. Journal of Stress Physiology & Biochemistry 8: 172–181.

    Google Scholar 

  26. Steer, K.A., T.M. Wallace, C.H. Bolton, and M. Hartog. 1997. Aspirin protects low density lipoprotein from oxidative modification. Heart 77: 333–337.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  27. Kirkova, M., E. Ivancheva, and E. Russanov. 1994. In vitro effects of aspirin on malondialdehyde formation and on activity of antioxidant and some metal-containing enzymes. Comparative Biochemistry and Physiology. Pharmacology, Toxicology and Endocrinology 108: 145–52.

    Article  CAS  PubMed  Google Scholar 

  28. Young, D.S. 1987. Implementation of SI units for clinical laboratory data. Annals of Internal Medicine 106: 114–129.

    Article  CAS  PubMed  Google Scholar 

  29. Espe, K.M., J. Raila, A. Henze, et al. 2011. Impact of vitamin A on clinical outcomes in haemodialysis patients. Nephrology, Dialysis, Transplantation 26: 4054–4061.

    Article  CAS  PubMed  Google Scholar 

  30. Podhaisky, H.P., A. Abate, T. Polte, S. Oberle, and H. Schröder. 1997. Aspirin protects endothelial cells from oxidative stress: possible synergism with vitamin E. FEBS Letters 417: 349–351.

    Article  CAS  PubMed  Google Scholar 

  31. Espe, K.M., J. Raila, A. Henze, et al. 2013. Low plasma a-tocopherol concentrations and adverse clinical outcomes in diabetic hemodialysis patients. Clinical Journal of the American Society of Nephrology 8: 1–7.

    Article  Google Scholar 

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Acknowledgments

We are grateful to Paula Garcia Chiarello, Alceu Afonso Jordão Júnior, and Paula Payão Ovidio for valuable discussions about this research, and we acknowledge financial support from CAPES-Brazil (Coordination for the Improvement of Higher Education Personnel—Brazil).

Conflict of Interest

The authors declare that they have no competing interests.

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Authors and Affiliations

  1. Division of Nephrology, Ribeirão Preto Medical School of University of São Paulo, Ribeirão Preto, SP, Brazil

    Fabíola Pansani Maniglia & José Abrão Cardeal da Costa

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  1. Fabíola Pansani Maniglia
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  2. José Abrão Cardeal da Costa
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Correspondence to Fabíola Pansani Maniglia.

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Maniglia, F.P., da Costa, J.A.C. Effects of Acetylsalicylic Acid Usage on Inflammatory and Oxidative Stress Markers in Hemodialysis Patients. Inflammation 39, 243–247 (2016). https://doi.org/10.1007/s10753-015-0244-8

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  • DOI: https://doi.org/10.1007/s10753-015-0244-8

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