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Insulin-Like Growth Factor 1 Treatment of MSCs Attenuates Inflammation and Cardiac Dysfunction Following MI

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Abstract

It has been reported that insulin-like growth factor 1 (IGF-1) promoted migration of endothelial cells and cardiac resident progenitor cells. In the previous study, we found the time-dependent and dose-dependent effects of IGF-1 treatment on the CXCR4 expression in MSCs in vitro, but it is still not clear whether IGF-1 pretreatment of MSCs may play anti-apoptotic and anti-inflammation role in myocardial infarction. In this study, we demonstrated that IGF-1-treated MSCs’ transplantation attenuate cardiac dysfunction, increase the survival of engrafted cells in the ischemic heart, decrease myocardium cells apoptosis, and inhibit protein production and gene expression of inflammation cytokines tumor necrosis factor alpha (TNF-α), interleukin (IL)-1β, and IL-6. IGF-1 pretreatment of MSCs may play anti-apoptotic and anti-inflammation roles in post-myocardial infarction.

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Acknowledgments

This project was supported by funds from the Youth Project of National Natural Science Foundation (81100078), Key Project of Chinese Ministry of Education (211207), Guangzhou Pearl River science and technology new star project plan (2012J2200063), and Guangdong Science and Technology Department (S2011040001392).

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Authors and Affiliations

  1. Department of Cardiology, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, People’s Republic of China

    Jun Guo, Dong Zheng, Wen-feng Li, Hai-rui Li, Ai-dong Zhang & Zi-cheng Li

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  1. Jun Guo
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  2. Dong Zheng
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  3. Wen-feng Li
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  4. Hai-rui Li
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  6. Zi-cheng Li
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Correspondence to Jun Guo or Zi-cheng Li.

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Guo, J., Zheng, D., Li, Wf. et al. Insulin-Like Growth Factor 1 Treatment of MSCs Attenuates Inflammation and Cardiac Dysfunction Following MI. Inflammation 37, 2156–2163 (2014). https://doi.org/10.1007/s10753-014-9949-3

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