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Cyane-carvone, a Synthetic Derivative of Carvone, Inhibits Inflammatory Response by Reducing Cytokine Production and Oxidative Stress and Shows Antinociceptive Effect in Mice

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Abstract

Cyane-carvone (CC) was studied to elucidate its anti-inflammatory, antinociceptive, and antioxidant effects in Mus musculus. Anti-inflammatory (bradykinin, histamine, prostaglandin E2, serotonin, and carrageenan) and antinociceptive (acetic acid and formalin) models were utilized. Myeloperoxidase activity, interleukin (IL)-1β, tumor necrosis factor alpha (TNF-α), and glutathione (GSH) levels were evaluated. Analysis of variance followed by Student-Newman-Keuls’ test was done. Results were compared with control groups (significantly when p < 0.05). In bradykinin, histamine, prostaglandin E2, and serotonin tests, 75 mg/kg CC decreased significantly paw edema (t = 30, 60, 90, and/or 120 min). In carrageenan test, 50 and 75 mg/kg CC (t = 3 h and t = 4 h) and 25 mg/kg CC (t = 4 h) decreased significantly paw edema. CC (75 mg/kg) inhibited significantly mieloperoxidase activity and decreased IL-1β and TNF-α, and all doses increased GSH levels. CC (75 mg/kg) decreased significantly the number of contortions of animals and time of licking (phase 2). CC showed anti-inflammatory, antinociceptive, and antioxidant effects in mice.

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Acknowledgments

This work was funded by the National Council for Scientific and Technological Development (CNPq) and Research Supporting Foundation of State of Piauí (FAPEPI/Brazil).

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Authors and Affiliations

  1. Laboratório de Pesquisa em Neuroquímica Experimental, Curso de Farmácia, Universidade Federal do Piauí, Campus Universitário Ministro Petrônio Portella, Bairro Ininga, 64049-550, Teresina, Piauí, Brazil

    Thiago Henrique Costa Marques, Maria Leonildes Boavista Gomes Castelo Branco Marques & Rivelilson Mendes de Freitas

  2. Laboratory of Experimental Physiopharmacology, Biotechnology and Biodiversity Center Research (BIOTEC), Federal University of Piauí (UFPI), Campus of Parnaíba, 64202-020, Parnaíba, PI, Brazil

    Jand-Venes R. Medeiros, Renan Oliveira Silva & André Luiz dos Reis Barbosa

  3. Post-Graduate Program in Pharmaceutics Sciences, Federal University of Sergipe, 49100-000, São Cristóvão, SE, Brazil

    Tamires Cardoso Lima

  4. Department of Pharmaceutical Science, Federal University of Paraiba, University Campus I, Castelo Branco District, 58051-900, João Pessoa, PB, Brazil

    Damião Pergentino de Sousa

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  1. Thiago Henrique Costa Marques
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Correspondence to Rivelilson Mendes de Freitas.

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Marques, T.H.C., Marques, M.L.B.G.C.B., Medeiros, JV.R. et al. Cyane-carvone, a Synthetic Derivative of Carvone, Inhibits Inflammatory Response by Reducing Cytokine Production and Oxidative Stress and Shows Antinociceptive Effect in Mice. Inflammation 37, 966–977 (2014). https://doi.org/10.1007/s10753-014-9817-1

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