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Long-Term Stability of Uveitis with Faint Anterior Chamber Flare Treated with Once-Daily Topical Ophthalmic Betamethasone


The aim of our study is to investigate the long-term transitions of intraocular pressure (IOP) and aqueous flare values in uveitis patients with faint anterior chamber flare who were treated with once-daily topical ophthalmic betamethasone for more than 6 months. The study included a total of 111 eyes of 68 outpatients. The mean follow-up period was 26.8 months. The average IOP and aqueous flare value of patients divided by the 5-months follow-up period showed no significant difference. Six eyes (of four patients) were followed-up for more than 1 year after termination of the treatment. Among these patients, the average aqueous flare value was significantly higher, and the average period to reach more than 1.5 times the former aqueous flare value significantly decreased after termination than before. Once-daily topical ophthalmic betamethasone is not expected to cause steroid-induced ocular hypertension but to have prophylactic effect.

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This study was supported in part by a Strategic Research Foundation Grant for the aid of Projects in Private Universities, offered by the Ministry of Education, Culture, Sports, Science, and Technology, Japan (MEXT), 2011–2015 (S1101027).

Role of the Sponsor

The sponsor had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; or preparation, review, or approval of the manuscript.

Conflict of Interest Disclosures

None reported.

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Correspondence to Masahiro Zako.

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Kawamura, M., Zako, M. Long-Term Stability of Uveitis with Faint Anterior Chamber Flare Treated with Once-Daily Topical Ophthalmic Betamethasone. Inflammation 37, 417–425 (2014).

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  • aqueous flare
  • betamethasone
  • intraocular pressure
  • steroid-induced ocular hypertension
  • uveitis