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Comparison of the Effects of Desflurane and Propofol Anesthesia on the Inflammatory Response and S100β Protein During Coronary Artery Bypass Grafting

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Abstract

Cardiopulmonary bypass (CPB) contributes to the secretion of anti-inflammatory cytokines that mediate the inflammatory response observed during open heart surgery. In addition to many factors, type of anesthesia management affects immune response and central nervous system in cardiac surgery. The aim of this study was to assess the effect of propofol versus desflurane anesthesia on systemic immune modulation and central nervous system on patients undergoing coronary artery bypass grafting. Forty patients undergoing elective coronary artery bypass graft surgery with CPB were included in this prospective randomized study. Patients were allocated to receive propofol (n = 20) or desflurane (n = 20) for maintenance of anesthesia. The blood samples for IL-6, IL-8, TNF-α, and S100β were drawn just prior to the operation before the induction of anesthesia, second before cardiopulmonary bypass, third after CPB, fourth 4 h postoperatively at the ICU. Major finding in our study is that S100β levels were lower in propofol group when compared to desflurane anesthesia. And also immune reaction was less in patients exposed to desflurane anesthesia when compared to propofol anesthesia as indicated by lower plasma concentrations of IL-8 and IL-6. Propofol is more preferable in terms of S100β for anesthetic management for CABG.

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Abbreviations

CPB time:

Cardiopulmonary bypass time

ICU:

intensive care unit

SD:

Standard deviation

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Acknowledgments

The authors acknowledge with gratitude the cooperation of people who collected and managed the database of our institution. This study was supported by Afyon Kocatepe University Scientific Research Projects unit (Project no: 12.TIP.26).

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Authors and Affiliations

  1. Department of Anesthesia and Reanimation, Faculty of Medicine, Afyon Kocatepe University, Ali Çetinkaya kampusü, Afyon-İzmir Karayolu8.km, 03200, Afyonkarahisar, Turkey

    Elif Doğan Baki, Serdar Kokulu, Yüksel Ela & Remziye Gül Sıvacı

  2. Department of Cardiovascular Surgery, Afyon Kocatepe University, Afyonkarahisar, Turkey

    Mustafa Aldemir & Fahri Adalı

  3. Department of Biochemistry, Afyon Kocatepe University, Afyonkarahisar, Turkey

    Halit Buğra Koca

  4. Clinic of Anesthesia and Reanimation, Antalya Training and Research Hospital, Antalya, Turkey

    Nilgün Kavrut Öztürk

  5. Clinic of Cardiovascular Surgery, Antalya Training and Research Hospital, Antalya, Turkey

    Mustafa Emmiler

  6. Department of Public Health, Afyon Kocatepe University, Afyonkarahisar, Turkey

    Hanife Uzel

Authors
  1. Elif Doğan Baki
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  2. Mustafa Aldemir
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Correspondence to Elif Doğan Baki.

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Baki, E.D., Aldemir, M., Kokulu, S. et al. Comparison of the Effects of Desflurane and Propofol Anesthesia on the Inflammatory Response and S100β Protein During Coronary Artery Bypass Grafting. Inflammation 36, 1327–1333 (2013). https://doi.org/10.1007/s10753-013-9671-6

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  • DOI: https://doi.org/10.1007/s10753-013-9671-6

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